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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Intensity of oxidative stress in pathophysiology
- Oxidative stress, chronic inflammation & fibrosis
- Oxidative stress
- Inflammatory cytokines with pro-fibrogenic effect
- ROS-secondary products diffuse much better
- Oxidation of LDL
- Lipid oxidation in athlerosclerotic lesions
- Molecules that provoke endothelial dysfunction
- Fibrotic plaque formation
- Inflammation-dependent vascular remodeling
- Athlerosclerotic plaque evolution
- MMP-9 accumulation in carotid plaques
- Lipid oxidation
- Oxidative modification of LDL lipid moiety
- Aldehydes produced from LDL oxidation
- Aldehyde modulation of cellular responses
- HNE adducts in a human carotid fibrotic plaque
- Reactions of 4-hydroxy-2-alkenals
- TGFβ-1 synthesis after HNE exposure
- HNE increases MCP-1 levels
- 4-hydroxynonenal and atherosclerosis
- LDL oxidation products
- Oxysterols of pathophysiological relevance
- Origin of plasma and tissue oxysterols (1)
- Origin of plasma and tissue oxysterols (2)
- Oxysterols
- Oxysterols in human fibroatheroma (1)
- Oxysterols in human fibroatheroma (2)
- The pro-atherogenic role of oxysterols
- Genes upregulated by oxysterol in U937 cells
- Proinflammatory effects of oxysterols (1)
- Proinflammatory effects of oxysterols (2)
- Proinflammatory effects of oxysterols (3)
- 27-OH markedly upregulates MMP-9 expression
- Inflammatory cytokines induce MMP-9
- Oxysterols and atheroma formation - summary
- Oxysterols and atherosclerosis
- Conclusions (1)
- Conclusions (2)
- Conclusions (3)
Topics Covered
- Oxidative stress, inflammation and fibrosis
- Redox-dependent expression of pro-fibrogenic cytokines
- Formation and evolution of fibrotic plaque: the primary role of inflammation
- LDL lipid oxidation products
- Lipid oxidation during the genesis of atherosclerotic lesion
- Enzymatic and non-enzymatic lipid oxidation products
- Pro-inflammatory and pro-fibrogenic effects of 4-hydroxy-2-alkenals
- Oxysterols of pathophysiological interest
- Oxysterols and atheroma formation
- Pro-inflammatory effects of cholesterol oxidation products
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Poli, G. (2019, September 26). Oxidative stress and disease: atherosclerosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/392/.Export Citation (RIS)
Publication History
Financial Disclosures
- Giuseppe Poli has no commercial/financial relationships to disclose.
A selection of talks on Immunology & Inflammation
Transcript
Please wait while the transcript is being prepared...
0:00
The title of this presentation
is Oxidative stress and
Disease: Atherosclerosis.
My name is Giuseppe Poli from
the Department of Clinical and
Biological Sciences,
University of Turin, Italy.
I would like to present and
discuss the recent available evidence
on the possible role of oxidative stress
in the pathogenesis of atherosclerosis.
0:30
Cellular oxidative stress is
a biochemical phenomenon occurring
under different conditions, and
characterized by different intensities.
Depending on the intensity of
the biochemical phenomenon,
we can have either modulation
of cell functions or
other physiological conditions,
like fibrosis and inflammation.
In case of a high intensity
of oxidative stress,
the cell develops irreversible damage.
1:09
In association with oxidative stress,
chronic inflammation and
fibrosis often occurs,
in several chronic human diseases
involving the lung, the liver,
the brain or the kidney.
Today we are interested in
atherosclerosis, a term which is
actually composed of two words:
'atheroma' and 'sclerosis'.
Atheroma means fibrotic plaque,
sclerosis is a similar term to fibrosis,
and
they mean the fibrotic
degeneration of the arterial wall.