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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Oxidative stress
- Cellular effects of oxygen radicals
- Sources of ROS - hypoxia
- Sources of ROS - inflammation
- Sources of ROS - UV radiation
- Consequence of hyperoxia
- Are ROS useful?
- ROS in fertilization
- ROS in embryogenesis
- ROS in implantation
- ROS in limb bud formation
- ROS: good or bad? a balancing act
- Oxidative stress induces antioxidant defense
- Important antioxidants
- Antioxidant vitamins
- Less traditional antioxidants
- Bilirubin as an antioxidant?
- Heme oxygenase regulates bilirubin production
- HO-1 gene
- Oxidative regulation of HO-1 (1)
- Oxidative regulation of HO-1 (2)
- HO-1 luciferase reporter construct
- Bench-top small animal imaging system
- HO-1/Luc activation in hyperoxia
- HO-1 knockouts
- Nitric oxide: the good
- Developmental regulation of NO byproducts
- Antioxidants: the more the merrier?
- Nitric oxide: the bad
- NO in neonatal chronic lung disease
- ROS and Down syndrome
- Deleterious effects of excess CuZn SOD
- Do ROS contribute to neonatal diseases?
- Upregulation of antioxidant defenses before birth
- Prematurity = disrupted development
- Examples for oxidative insults
- ROS in bronchopulmonary dysplasia (BPD)
- ROS in periventricular leukomalacia (PVL)
- ROS in necrotizing enterocolitis (NEC)
- ROS in retinopathy of prematurity (ROP)
- Clinical trials with antioxidants in neonates
- Therapeutic interventions: superoxide dismutase
- Therapeutic interventions: N-acetylcysteine
- Therapeutic interventions: glutathione
- Therapeutic interventions: vitamin C
- Therapeutic interventions: vitamin E
- Therapeutic interventions: nitric oxide
- Clinical trials of NO - no benefits
- Clinical trials of NO - worrisome effect
- Clinical trials of NO - beneficial effect
- Clinical trials of NO - lung protective effect
- Clinical trials of NO - neuroprotective effects
- Is NO related to decrease oxidative stress?
- No impresive beneficial effects for antioxidants
- Therapeutic interventions: what do we do?
- Balance
- Acknowledgments
Topics Covered
- Cellular effects of oxygen radicals
- Sources of ROS
- Hyperoxia
- ROS in various processes
- ROS: good or bad?
- Important antioxidants
- Antioxidant vitamins
- Less traditional antioxidants
- HO-1 gene
- Nitric oxide
- ROS and Down syndrome
- ROS contribution to neonatal diseases
- Clinical trial with antioxidants in neonates
Links
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Talk Citation
Dennery, P. (2007, November 1). Oxidative stress in development and neonatal diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/389/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Phyllis Dennery has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.