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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- The author
- Vitamin E structure: the different tocopherols
- Antioxidants with different biological functions
- The discovery of vitamin E
- The antioxidant function of vitamin E
- Recycling of vitamin E
- Problems of interpretation
- Tocopherol transfer protein (TTP)
- Unique uptake of alpha-tocopherol
- Inhibition of protein kinase C by tocopherol
- Ed Fisher: discovery of protein phosphorylation
- Nishizuka and protein kinase C
- PKC inhibition by different tocopherols
- Phosphatase activation and PKC inhibition
- Different effects of alpha and beta tocopherols
- Inhibition of NADPH-oxidase assembly
- Inhibition of CD36 gene transcription
- Uptake of oxidized LDL is inhibited by tocopherol
- A number of genes are regulated by tocopherol
- Structure of tocopherol associated protein (TAP)
- Specificity of alpha-tocopherol binding to TAP
- TAP has GTPase activity
- Tocopherol and PI3 kinase
- The PI3 kinase and PKC regulation system
- Protection of vitamin against radicals
- A scheme of molecular events in atherogenesis
- The contradictory results of population studies
- Protection of tocopherol against cancer
- Several pathologies are prevented by vitamin E
- Vitamin E in animal studies
- Tocopheryl phosphate is a natural molecule
- Tocopheryl phosphate is synthesized in cells
- No cytotoxicity of tocopheryl phosphate
- Tocopheryl phosphate and atherogenesis
- Inhibition of superoxide production
- Inhibition of CD36 expression
- Tocopheryl phosphate inhibits cell proliferation
- Tocopheryl phosphate conversion to tocopherol
- Tocopherol uptake by cells
- The structure of glybenclamide
- Glybenclamide and tocopherylphosphate uptake
- Effect of glybenclamide on cell proliferation
- Molecular effects of tocopheryl phosphate
- Diet TP is not converted to tocopherol
- Tocopheryl phosphate vs. tocopheryl acetate
- Tocopherol and tocopheryl phosphate action
- Thank you
Topics Covered
- Vitamin E or tocopherol's physiological molecular mechanism helps to understand protection against disease
- Not an antioxidant or free radical quencher, they perform cell signaling by affecting protein phosphorylation (for instance protein kinase C and PI3 kinase)
- They can be phosphorylated to more potent species, the tocopheryl phosphates
- Tocopheryl phosphates protect, in animal models against atherosclerosis
Links
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Talk Citation
Azzi, A. (2017, October 21). Cell signaling by vitamin E [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/387/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Angelo Azzi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.