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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Why the name SOD
- SOD - only enzyme known to act on radicals
- Reactions involving superoxide
- SOD - part of the antioxidant defense system
- SODs of eukaryotic cells
- Human Cu-Zn SOD
- Copper-zinc superoxide dismutase protein
- CuZnSOD activity
- CuZnSOD transcripts
- The CuZnSOD gene
- Transcriptional regulation of CuZnSOD
- Mutations of CuZnSOD gene and FALS
- Human MnSOD
- Manganese superoxide dismutase protein
- Inactivation of human MnSOD
- MnSOD transcripts
- The MnSOD gene
- Transcriptional regulation of MnSOD
- MnSOD function
- Extracellular superoxide dismutase protein (1)
- Extracellular superoxide dismutase protein (2)
- Extracellular superoxide dismutase protein (3)
- ECSOD activity
- Inactivation of ECSOD
- ECSOD transcripts
- The ECSOD gene (1)
- Transcriptional regulation of ECSOD (1)
- Transcriptional regulation of ECSOD (2)
- The ECSOD gene (2)
- SODs modulate redox signaling?
- Superoxide can act as oxidant or reductant
- Superoxide targets kinases and phosphatases
- SODs: do they really matter?
- Acknowledgments
- References (1)
- References (2)
- References (3)
- References (4)
- References (5)
- References (6)
- References (7)
Topics Covered
- Superoxide dismutase
- Eukaryotic cell SODs
- Copper-Zinc Superoxide Dismutase (CuZnSOD) protein
- CuZnSOD activity
- CuZnSOD transcripts
- The CuZnSOD gene
- Manganese Superoxide Dismutase (MnSOD) protein
- MnSOD transcripts
- The MnSOD gene
- MnSOD function
- Extracellular Superoxide Dismutase (ECSOD) protein
- ECSOD activity
- ECSOD transcripts
- The ECSOD gene
- SODs modulate redox signaling?
- SODs: do they really matter?
Talk Citation
St. Clair, D. (2017, October 21). The SODs [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/384/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Daret St. Clair has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.