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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Aims
- Intracellular proteases
- The 20S 'core' proteasome
- Properties of the 20S 'core' proteasome
- Proteasomal particles
- The proteasome-ubiquitin system
- The proteasomal system
- Hypothesis: protein oxidation and proteasome
- Degradation of oxidized proteins: 'in vitro' studies
- Degradation of hydrogen peroxide-oxidized ferritin
- Degradation of ferritin oxidized by other oxidants
- Oxidation, degradation and protein function: ferittin
- Oxidation and protein function: GAPDH
- Degradation of oxidized GAPDH
- Degradation of oxidized proteins in vitro - summary
- Protein surface hydrophobicity
- Degradation of oxidized RNase A
- FT-IR spectra of RNase A
- Changes in RNase due to oxidation
- Unfolding of oxidized proteins
- Stability of the 20S proteasome towards oxidation
- Degradation by the proteasome in vitro - summary
- Degradation of oxidized proteins: mammalian cells
- Oxidative stress and protein turnover
- Proteasome-dependent increased proteolysis
- Stability towards oxidation: 26S vs. 20S form
- Loss of E1 and ubiquitination in E36ts20 cells
- Degradation of oxidized proteins in E1 mutants
- Degradation of oxidized proteins in cells: summary
- What happens if degradation fails ?
- Protein aggregates inhibit the proteasome
- Particle uptake by fibroblasts
- Proteolytic activity during lipofuscin treatment
- Proteasome activity in Alzheimer disease brain
- PHFs bind to the proteasome
- Summary
- Acknowledgment
Topics Covered
- Oxidized proteins
- Intracellular proteases
- The 20S core proteasome
- Proteasomal particles
- The proteasome-ubiquitin system
- Protein oxidation and proteasome
- Degradation of oxidized proteins and protein function
- Protein surface hydrophobicity
- Unfolding of oxidized proteins
- Stability of the 20S proteasome towards oxidation
- Oxidative stress and protein turnover
- Oxidation-induced proteolysis
- Degradation of oxidized proteins in cells
- What happens if degradation fails?
- Protein aggregates inhibit the proteasome
- Particle uptake by fibroblasts
Talk Citation
Grune, T. (2007, November 1). Protein oxidation and removal of oxidized proteins by proteolysis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/383/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Tilman Grune has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.