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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Formation of reactive oxygen species
- Metal ion-catalyzed Haber-Weiss reaction
- Sites of oxidative damage in DNA
- Types of DNA damage by free radicals
- Reactions of hydroxyl radical with purines
- Formation of purine products
- Formation of 8,5'-cyclopurine-2'-deoxynucleosides
- Products of oxidative damage to DNA bases
- Measurement of DNA damage and repair
- Biological responses to genomic DNA damage
- Pathways for processing of a DNA lesion in cells
- Mutagenesis by oxidative DNA damage products
- Mechanisms of base-excision repair
- Activity of a DNA glycosylase
- Repair of 8,5'-cyclopurine-2'-deoxynucleosides
- DNA glycosylases in base-excision repair
- Substrate specificities of DNA glycosylases (1)
- Substrate specificities of DNA glycosylases (2)
- Determination of excision by a DNA glycosylase
- Basic equations of enzyme kinetics
- Substrates of E. coli Fpg
- Substrates of eukaryotic OGG1 proteins
- Excision by polymorphic variants of human OGG1
- Substrates of E. coli endonuclease III (Nth)
- Substrates of E. coli Nei
- Substrates of DNA glycosylases - summary
- In vivo assays of NTH1 and OGG1activity (1)
- In vivo assays of NTH1 and OGG1activity (2)
- DNA lesions in DNA of NTH1 and OGG1 KO mice
- Role of NEIL1 in disease
- Mouse and human NEIL1 proteins
- Substrates of human and mouse NEIL1 proteins
- Conservation of human NEIL1
- Activities of human NEIL1 variants
- Excision by polymorphic variants of human NEIL1
- Frequency of polymorphic variants of human NEIL1
- DNA lesions in organs of neil1 knockout mice
- Metabolic syndrome phenotype in neil1 KO mice
- Cockayne syndrome
- CSB structure and location of designed mutants
- Activity of extracts of wt and CSB-mutant cells
- 8-hydroxy-2'-deoxyadenosine in CSB mutant cells
- DNA lesions in fibroblasts from CSB patients
- Collaborators
Topics Covered
- Formation of reactive oxygen species
- Oxidative damage to DNA bases by free radicals
- Techniques used for the measurement of DNA damage and repair
- Biological responses to genomic DNA damage
- Mechanisms of base-excision repair
- Determination of substrate specificities of DNA glycosylases in-vitro and in-vivo
- Mouse and human NEIL1 proteins
- Cockayne syndrome
- CSB protein
Talk Citation
Dizdaroglu, M. (2007, November 1). Oxidative DNA damage: mechanisms, repair and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/380/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Miral Dizdaroglu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.