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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Radicals and diseases
- Forms of reactive oxigen species (ROS)
- Outline
- Names and abbreviations
- Historical overview
- The paradox of oxygen
- Cu,Zn-superoxide dismutase (SOD)
- Fe,Mn-SOD
- Superoxide formation (1)
- Superoxide formation (2)
- The Haber-Weiss reaction
- Radical chemistry: the Fenton reaction
- History of Fenton reaction
- The product of Fenton reaction
- Fenton reaction discovery - a case of serendipity
- Radical chemistry: the Haber-Weiss cycle
- Characteristics of radicals involved in the cycle
- Role of iron ions in the cycle
- Researchers who contributed to cycle discovery
- Criticism by P. George
- Two possible mechanisms
- Conclusion of P. George research
- Mechanism for hydrogen-peroxide decomposition
- Haber-Weiss cycle: conclusions
- Kinetics of the Fenton reaction
- Possible oxidizing agents in the Fenton reaction
- Remarks and questions regarding Fenton reaction
- Fenton reaction vs. reacion with catalase
- In vivo protection: SOD or catalase?
- Generation of radicals by ionising radiation
- Interconversion of radicals
- Generation of radicals by flash photolysis
- Detection of radicals
- Thermodynamics of superoxide
- Electrode potentials
- Redox potential of superoxide/dioxygen couple (1)
- Redox potential of superoxide/dioxygen couple (2)
- Gibbs free energy for superoxide redox (1)
- Gibbs free energy for superoxide redox (2)
- Oxidation state diagram for oxygen
- Reduction of hydrogen-peroxide by superoxide
- Superoxide reactivity and catalysis by SOD
- Hydrogen-peroxide properties
- Hydroxyl radical properties
- Radicals in cells - summary
- Finding the role of SOD in physiology
- Formation of peroxynitrite
- Peroxynitrite formation in cells (1)
- Nitrogen-monoxide in living cells
- Peroxynitrite formation in cells (2)
- Properties of peroxynitrite
- Peroxynitrite and carbon-dioxide
- Concluding remarks
Topics Covered
- Oxy radicals and peroxides: superoxide, hydrogen peroxide, hydroxyl, peroxynitrite
- Generation by ionizing radiation and by flash photolysis
- Reactivity
- Thermodynamics, electrode potentials and kinetics
- Fenton chemistry
Talk Citation
Koppenol, W. (2007, November 1). The chemistry and biochemistry of partially reduced oxygen species [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/375/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Willem Koppenol has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.