• Introduction to the complement system
• 19 min
  1. The complement system - an introduction for undergraduates

  • Prof. Michael Holers
  • Dr. Ashley Frazer-Abel
• 50 min
  2. The classical pathway of complement

  • Prof. Mohamed R. Daha
• 34 min
  3. The evolution of complement and the alternative pathway

  • Prof. Sir Peter Lachmann
• 42 min
  4. Complement and T cells

  • Prof. Claudia Kemper
• 49 min
  5. Physiopathological implications of genetic variability in the complement alternative pathway

  • Prof. Santiago Rodríguez de Córdoba
• The complement in human diseases
• 20 min
  6. Subversion of the complement system by viruses

  • Dr. Arvind Sahu
• 31 min
  7. Subversion of complement by bacteria

  • Prof. Seppo Meri
• 26 min
  8. Complement deficiencies in humans

  • Prof. Francesco Tedesco
• 33 min
  9. C3 glomerulopathy

  • Prof. Matthew Pickering
• 20 min
  10. Complement 3 glomerulopathy (C3G) and haemolytic uraemic syndrome (HUS)

  • Prof. David Kavanagh
• 42 min
  11. Complement and lupus

  • Prof. Marina Botto
• 30 min
  12. Complement in PNH and other hemolytic anaemias 1

  • Prof. Lucio Luzzatto
• 24 min
  13. Complement in PNH and other hemolytic anaemias 2

  • Prof. Lucio Luzzatto
• 27 min
  14. Complement in PNH and other hemolytic anaemias 3

  • Prof. Lucio Luzzatto
• Other topics
• 37 min
  15. Complement diagnostics

  • Dr. Ashley Frazer-Abel
• 43 min
  16. Complement as a therapeutic target

  • Prof. Claire Harris
• 51 min
  17. Complement and organ transplantation

  • Prof. Steven Sacks

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Navigable Slide Index

1. Introduction
2. Main features of the complement system
3. Recognition molecules of the complement system
4. Activation pathways of the complement system
5. Effector phase of the complement system
6. Inherited complement deficiencies in humans
7. Deficiencies of the classical pathway (1)
8. Deficiencies of the classical pathway (2)
9. Classical pathway deficiencies: clinical conditions
10. Classical pathway deficiencies: SLE (1)
11. Classical pathway deficiencies: manifestations
12. Classical pathway deficiencies: SLE (2)
13. C2 deficient patients with SLE/SLE-like syndrome
14. Classical pathway deficiencies: bacterial infections
15. Bacterial infections: early components deficiency
16. Strains of bacteria causing infections
17. Deficiencies of the alternative pathway (1)
18. Deficiencies of the alternative pathway (2)
19. Deficiencies of components of the lectin pathway
20. MBL deficiency (1)
21. MBL deficiency (2)
22. C3 deficiency
23. Deficiencies of the terminal pathway (1)
24. Deficiencies of the terminal pathway (2)
25. Neisserial infections: late component deficiencies
26. Characteristics of meningococcal disease
27. Meningococcal serogroups in various countries
28. Deficiencies of complement regulators
29. Complement regulators
30. Clinical features of hereditary angioedema (1)
31. Types of hereditary angioedema
32. Clinical features of hereditary angioedema (2)
33. Complement regulators: CD55
34. CD55 deficiency (1)
35. CD55 deficiency (2)
36. Dysregulation of the alternative pathway: diseases
37. Complement regulators: CD59
38. CD59 deficiency
39. Laboratory investigation of the complement system
40. Treatment of patients with inherited deficiencies
41. Replacement of the missing protein
42. Infections management in complement deficiency
43. Conclusions

Topics Covered

• Organization and functions of the complement system
• Frequency of inherited deficiencies in the general population
• Deficiencies of components and regulators of the complement system and their disease association
• Diagnostic approaches and therapeutic strategies to identify and to control the complement defects

Links

Series:

• The Complement System

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 30, 2018

Financial Disclosures

• Prof. Francesco Tedesco has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.