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- General Virology
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1. Principles of virology
- Prof. Vincent Racaniello
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2. The type I interferon system and viruses
- Dr. Adolfo Garcia-Sastre
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3. Immune responses to viruses
- Prof. Paul Klenerman
- Emerging Pathogens
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4. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide
- Dr. Marietjie Venter
- Mrs. Orienka Hellferscee
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5. Emerging respiratory viruses - discoveries between 2001 and 2005
- Prof. Ron Fouchier
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6. Usage of vaccines and therapeutics in public health emergencies 1
- Prof. Gary Kobinger
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7. Usage of vaccines and therapeutics in public health emergencies 2
- Prof. Gary Kobinger
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8. Influenza virus pandemics: past and future
- Prof. Peter Palese
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9. SARS-CoV and other emerging coronaviruses
- Prof. Ralph Baric
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10. Dengue, Zika and Chickungunya viruses
- Prof. Ana Fernandez-Sesma
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11. Paramyxoviruses: biology & pathogenesis
- Prof. Benhur Lee
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12. Antiviral drugs (non-HIV)
- Prof. Megan Shaw
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13. Biodefense challenges
- Dr. David Franz
- Important Pathogens and their Diseases
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14. Natural history and pathogenesis of herpes virus infections
- Prof. Richard Whitley
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15. Cytomegalovirus biology
- Prof. Domenico Tortorella
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16. Hepatitis C virus: discovery, cure and protection
- Dr. Matthew Evans
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17. Fundamentals of HIV biology
- Prof. Viviana Simon
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18. Measles
- Prof. Diane E. Griffin
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19. Monkeypox virus, vaccines, and therapeutics
- Prof. Rachel Roper
- New Frontiers
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22. Viruses as anticancer weapons
- Prof. Roberto Cattaneo
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23. Novel approaches to diagnosis of viral infections
- Prof. W. Ian Lipkin
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24. The Global Virus Network: collaboration to address pandemic and regional threats
- Prof. Sten H. Vermund
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25. Elite controllers of HIV: from discovery to future therapies
- Prof. Bruce Walker
- Archived Lectures *These may not cover the latest advances in the field
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26. Principles of virology I
- Prof. Richard Condit
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27. Principles of virology II
- Prof. Richard Condit
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28. Complex DNA viruses: herpes virus
- Dr. John Blaho
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29. Adeno-associated viruses (AAV)
- Prof. Kenneth Berns
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30. Poxviruses: smallpox (variola), vaccinia and monkeypox
- Prof. Paula Traktman
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31. Can HPV testing be the sole primary cervical screening modality?
- Prof. Jack Cuzick
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32. From viruses to oncolytics
- Prof. Roberto Cattaneo
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33. Non HIV antivirals
- Prof. Mary Klotman
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34. Gastroenteritis viruses
- Prof. Mary Estes
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35. Biodefense challenges
- Dr. Connie Schmaljohn
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37. The past, present and future of vaccination
- Prof. Stanley Plotkin
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38. Filoviruses
- Dr. Christopher Basler
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39. Bunyaviruses
- Prof. Richard Elliott
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40. The immunobiology of HIV
- Prof. Norman Letvin
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41. Hepatitis C and HCV
- Prof. Stanley Lemon
Printable Handouts
Navigable Slide Index
- Introduction
- Disclosure
- Outline of presentation
- Cancers attributable to HPV infection
- HPV types associated with cervical cancer
- Progression of cervical HPV infections to cancer
- Natural history of cervical HPV infection
- Key features of HPV pathogenesis
- Genital warts
- Laboratory of cellular oncology, CCR, NCI
- Developing preventive HPV vaccine challenges
- A prophylactic vaccine
- Formation of papillomavirus virions
- L1 self-assembles to form virus-like particles
- L1 VLP induction of neutralizing antibodies
- Systemic VLP vaccination in animal models
- Two HPV VLP vaccines are under development
- Merck: phase III prophylactic efficacy results
- Possible long term protection by HPV vaccine
- Cross-protection against other HPV types
- Preventing HPV cervical disease efficacy
- HPV life cycle
- How could vaccine prevent mucosal infection
- How could vaccine prevent cutaneous infection
- L1 VLPs are unlikely to be directly therapeutic
- Will the vaccines influence prevalent infection?
- Outstanding medical issues
- Regulatory status of HPV VLP vaccines
- Gardasil phase III adolescent study
- Percentage of sexually active teenagers in USA
- Disease progression by HPV status at entry
- We can't give up screening
- Cervical cancer prevention by Pap screening
- HPV-based cervical cancer prevention strategy
- HPV vaccination in developing nations
- Limitations of current VLP vaccines
- Potential reduction in cervical cancer
- Papillomaviruses neutralized by BPV1 L2
- Vaccination with L1-Salmonella live vaccine
- Summary and conclusions
Topics Covered
- Cervical cancer is attributable to multiple HPV types; HPV16 predominates
- Cervical cancer: time line of cervical HPV infections, progression and natural history
- Key features of HPV pathogenesis
- Challenges to development of a preventive HPV vaccine
- A prophylactic vaccine
- Formation of papillomavirus virions
- Two distinct HPV VLP vaccines are under commercial development
- Partial crossprotection against incident infection by other high risk HPV types
- Overall efficacy in preventing HPV cervical disease attributable to incident infection
- HPV life cycle
- How could IM injection of a VLP vaccine prevent mucosal or cutaneous infection at the cervix?
- Outstanding medical issues
- Regulatory status of HPV VLP vaccines
- Pap smear screening without vaccination would prevent more cervical cancer deaths than HPV16/18 vaccination without pap screening
- Limitations of current VLP vaccines
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Lowy, D. (2007, October 1). Papillomaviruses and HPV vaccination to prevent cervical cancer and other HPV-associated diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/YOLG3023.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Douglas Lowy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Papillomaviruses and HPV vaccination to prevent cervical cancer and other HPV-associated diseases
A selection of talks on Microbiology
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