• Overview of Molecular Chaperones
• 34 min
  1. History of the molecular chaperone concept: roles in assembly processes

  • Prof. Emeritus R. John Ellis
• 34 min
  2. Chaperone mechanisms in cellular protein folding

  • Prof. Dr. F. Ulrich Hartl
• Prokaryotic Molecular Chaperones
• 38 min
  3. Mechanistic aspects of chaperonin GroEL/ES function

  • Prof. Amnon Horovitz
• 99 min
  4. Structure and function of the ATP-dependent Clp chaperone/protease machines

  • Dr. Michael R. Maurizi
• 32 min
  5. The role of chaperones and Sec machinery in protein secretion

  • Prof. Koreaki Ito
• 44 min
  6. How can molecular chaperones repair damaged protein structures?

  • Prof. Pierre Goloubinoff
• 32 min
  7. Disulfide bond formation in vivo

  • Prof. James Bardwell
• Eukaryotic Molecular Chaperones
• 39 min
  8. Overview of eukaryotic molecular chaperones in the cytosol

  • Dr. Jason C. Young
• 36 min
  9. Chaperonin-containing TCP-1 (CCT), actin springs, and protein folding fluxes

  • Prof. Keith Willison
• 35 min
  10. The functions of the Hsp70 system

  • Prof. Jeffrey L. Brodsky
• 26 min
  11. Hsp90: a chaperone for protein kinases and hormone receptors

  • Dr. David Toft
• Role of Chaperones in Diseases
• 38 min
  12. The roles of molecular chaperones in bacterial infection

  • Prof. Tomoko Yamamoto
• 46 min
  13. Role of chaperonin-like proteins in Bardet-Biedl syndrome

  • Dr. Michel R. Leroux
• 53 min
  14. Roles for molecular chaperones in cystic fibrosis

  • Prof. Douglas M. Cyr
• 51 min
  15. Targeting cancer: designing drugs against Hsp90

  • Dr. Gabriela Chiosis
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  16. Overview of prokaryotic molecular chaperones

  • Prof. Walid A. Houry
• 47 min
  17. The biogenesis of E. coli inner membrane proteins

  • Dr. Joen Luirink
• 39 min
  18. Mechanism of chaperone action of small heat shock proteins

  • Prof. Elizabeth Vierling
• 22 min
  19. ClpB: a chaperone for protein disaggregation

  • Prof. Michal Zolkiewski
• 38 min
  20. The roles of chaperonins in bacteria

  • Dr. Peter Lund
• 44 min
  21. Towards a unifying mechanism for the Hsp70 chaperones

  • Prof. Pierre Goloubinoff
• 29 min
  22. Adaptor mediated activation of the Hsp100/ Clp protein ClpC controls general and regulatory proteolysis in Bacillus subtilis

  • Prof. Dr. Kursad Turgay
• 33 min
  23. Hsp31: a general stress protein of Escherichia coli

  • Prof. Francois Baneyx
• 46 min
  24. Hsp104: a specialized chaperone for protein disaggregation

  • Dr. John R. Glover
• 47 min
  25. Molecular chaperones and handling of abnormal proteins in neurodegenerative disorders

  • Prof. Michael Sherman
• 20 min
  26. The role of chaperones in Parkinson's disease

  • Dr. Konstanze F. Winklhofer

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Neurodegenerative disorders
3. Neurodegenerative disorders - inclusion bodies
4. Fate of a protein in the cell
5. Mutations in UPS components and chaperones
6. The ubiquitin-proteasome system
7. Role of CHIP in protein degradation
8. The aggresome
9. Tracing aggresome formation
10. Microtubules important for aggresome formation
11. Protective role of the aggresome
12. Role of HDAC6 in aggresome formation
13. Molecular chaperones and neurodegeneration
14. Hsp70 overexpression and Kennedy's disease
15. Hsp70 overexpression in Drosophila
16. CHIP overexpression and Kennedy's disease
17. Chemical induction of heat-shock proteins
18. Stress and induction of heat-shock proteins
19. Heat shock response
20. Defects in chaperone system
21. Chaperones in Huntington's disease model
22. Heat shock response in polyQ-expressing cells
23. Defects in UPS
24. Measurements of proteasome activity in a cell
25. UPS activity inhibition in cells with aggresomes
26. Proteasome subunits and Hsp70 in PD brain
27. Chaperone system and UPS defects with aging
28. Aging signaling pathways
29. Decrease in chaperone expression upon aging
30. Decrease in proteasome activity upon aging
31. Generation of Ubb+1 frameshift mutation
32. Age-dependence of aggregation
33. Aggregation in long-lived C. elegans mutants
34. Neurological problems and aging

Topics Covered

• Aggregation of proteins associated with neurodegenerative disorders
• Mechanisms of aggresome formation
• Suppression of the heat shock response in aging and neurodegeneration
• Role of heat shock proteins in suppression of apoptosis and senescence programs

Links

Series:

• Molecular Chaperones

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Michael Sherman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.