• Overview of Molecular Chaperones
• 34 min
  1. History of the molecular chaperone concept: roles in assembly processes

  • Prof. Emeritus R. John Ellis
• 34 min
  2. Chaperone mechanisms in cellular protein folding

  • Prof. Dr. F. Ulrich Hartl
• Prokaryotic Molecular Chaperones
• 38 min
  3. Mechanistic aspects of chaperonin GroEL/ES function

  • Prof. Amnon Horovitz
• 99 min
  4. Structure and function of the ATP-dependent Clp chaperone/protease machines

  • Dr. Michael R. Maurizi
• 32 min
  5. The role of chaperones and Sec machinery in protein secretion

  • Prof. Koreaki Ito
• 44 min
  6. How can molecular chaperones repair damaged protein structures?

  • Prof. Pierre Goloubinoff
• 32 min
  7. Disulfide bond formation in vivo

  • Prof. James Bardwell
• Eukaryotic Molecular Chaperones
• 39 min
  8. Overview of eukaryotic molecular chaperones in the cytosol

  • Dr. Jason C. Young
• 36 min
  9. Chaperonin-containing TCP-1 (CCT), actin springs, and protein folding fluxes

  • Prof. Keith Willison
• 35 min
  10. The functions of the Hsp70 system

  • Prof. Jeffrey L. Brodsky
• 26 min
  11. Hsp90: a chaperone for protein kinases and hormone receptors

  • Dr. David Toft
• Role of Chaperones in Diseases
• 38 min
  12. The roles of molecular chaperones in bacterial infection

  • Prof. Tomoko Yamamoto
• 46 min
  13. Role of chaperonin-like proteins in Bardet-Biedl syndrome

  • Dr. Michel R. Leroux
• 53 min
  14. Roles for molecular chaperones in cystic fibrosis

  • Prof. Douglas M. Cyr
• 51 min
  15. Targeting cancer: designing drugs against Hsp90

  • Dr. Gabriela Chiosis
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  16. Overview of prokaryotic molecular chaperones

  • Prof. Walid A. Houry
• 47 min
  17. The biogenesis of E. coli inner membrane proteins

  • Dr. Joen Luirink
• 39 min
  18. Mechanism of chaperone action of small heat shock proteins

  • Prof. Elizabeth Vierling
• 22 min
  19. ClpB: a chaperone for protein disaggregation

  • Prof. Michal Zolkiewski
• 38 min
  20. The roles of chaperonins in bacteria

  • Dr. Peter Lund
• 44 min
  21. Towards a unifying mechanism for the Hsp70 chaperones

  • Prof. Pierre Goloubinoff
• 29 min
  22. Adaptor mediated activation of the Hsp100/ Clp protein ClpC controls general and regulatory proteolysis in Bacillus subtilis

  • Prof. Dr. Kursad Turgay
• 33 min
  23. Hsp31: a general stress protein of Escherichia coli

  • Prof. Francois Baneyx
• 46 min
  24. Hsp104: a specialized chaperone for protein disaggregation

  • Dr. John R. Glover
• 47 min
  25. Molecular chaperones and handling of abnormal proteins in neurodegenerative disorders

  • Prof. Michael Sherman
• 20 min
  26. The role of chaperones in Parkinson's disease

  • Dr. Konstanze F. Winklhofer

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Talk outline
3. Protein targeting
4. Protein targeting and secretion in E. coli
5. SRP-mediated targeting
6. Conservation of the SRP/SR
7. Cryo-EM structure of ribosome-SRP complex
8. Co-translational targeting by the SRP
9. Specific aspects of E. coli SRP
10. Trigger factor
11. SecYEG
12. Crystal structure of the Sec-translocon
13. Biogenesis of two model E. coli IMPs
14. The model proteins
15. In vitro translation and cross-linking
16. Studying FtsQ and Lep
17. Cross-linking 108FtsQ
18. A dual role of YidC in IMP integration
19. Properties of YidC
20. Interactions in FtsQ membrane integration (1)
21. Interactions in FtsQ membrane integration (2)
22. Membrane integration of Lep H1
23. Two models of membrane integration
24. Rapid movement of H1 into lipid bilayer
25. Membrane integration of Lep H2
26. Membrane integration of Lep - summary
27. Substrate specificity of YidC
28. YidC depletion affects F1F0 ATPase biogenesis
29. YidC depletion affects Cyo oxidase biogenesis
30. Properties of F0c and CyoA
31. Membrane assembly of F0c
32. Membrane assembly of CyoA
33. E. coli membrane proteins biogenesis
34. YidC: molecular chaperone and insertase?
35. X-ray structure of SecYEG
36. People and projects
37. Acknowledgements

Topics Covered

• SRP-mediated targeting to the inner membrane
• Structure and function of the Sec-translocon in membrane insertion
• Role of YidC as an insertase and membrane chaperone

Links

Series:

• Molecular Chaperones

Categories:

• Biochemistry
• Cell Biology
• Microbiology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Dr. Joen Luirink has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.