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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- The Asian continent
- Human expansion "out of Africa"
- Two postulated routes out of Africa
- Pakistan and its neighbors
- Ethnic groups from Northern Pakistan
- Ethnic groups from Southern Pakistan
- DNA structure
- Karyogram of a human male
- Organization of the human genome
- Genetic markers for population analyses
- Polymerase chain reaction (PCR)
- DNA amplification by PCR
- Alu polymorphisms
- Microsatellites or short tandem repeats (STRs)
- Single nucleotide polymorphisms
- DHPLC
- SNP detection using DHPLC
- DNA sequencing
- DNA sequencing showing SNP
- Biallelic markers identify stable lineages
- Microsatellites and biallelic markers traits
- Ancestry proportion based on Alu polymorphism
- Continental phylogenetics
- PCA of grouped world populations
- Structure analysis of world populations
- Structure analysis of Asian populations
- Autosomal microsatellites
- The Y chromosome is inherited paternally
- Mitochondrial DNA markers used for analysis
- Asian Y-lineages
- Worldwide distribution of Y lineages
- Y lineages in West Asia
- PCA of populations from the Middle East
- Y-lineage O3 (M122) is common in China
- Distribution of Y lineages in Japan
- Comparison of Indian and Eurasian populations
- Spread of Y lineages in Asia
- R1a1 lineage in the Indo-Pak sub-continent
- R2 lineage in the Indo-Pak sub-continent
- Distribution of L1 lineage in India and Pakistan
- Median joining network of L lineages in Pakistan
- Indo-Pak mitochondrial lineages
- Mitochondrial lineages
- mtDNA variation in West Asia and Pakistan
- HLA genotyping by PCR
- Phylogenetic tree of HLA
- Correspondence analysis based on HLA
- Genetic signature of Alexander's invasion?
- Genetic signature of Mongol invaders
- Pakistani population origins: Hazara
- Pakistani population origins: Kalash
- Pakistani population origins: Parsi
- Pakistani population origins: Negroid Makrani
- Pakistani population origins: Hunza Burusho
- Summary
- Conclusions (1)
- Conclusions (2)
- Thank you
Topics Covered
- Population genetics
- Pakistan and south west Asia
- Human migrations
- DNA markers
- Alu repeats, SNPs and STRs
- Y chromosome, mitochondrial DNA and HLA markers unravel genetic relationships among populations in Asia and Pakistan
Talk Citation
Mehdi, S.Q. (2007, October 1). Genetics of Pakistani populations in an Asian and global context [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/325/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. S. Qasim Mehdi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.