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1. Genetics and management of inherited cancer predisposition 1
- Prof. Joshua Schiffman
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2. Genetics and management of inherited cancer predisposition 2
- Prof. Joshua Schiffman
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3. The cytogenetics of childhood acute leukemia
- Dr. Susana C. Raimondi
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4. Chromosome translocations and cancer
- Prof. Felix Mitelman
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5. Acute myeloid leukemia: genetics, prognosis and treatments
- Prof. Stephen Nimer
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6. Genetic abnormalities in acute lymphoblastic leukemia
- Prof. Ching Hon Pui
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7. Molecular genetics of non-Hodgkin lymphoma
- Prof. Jude Fitzgibbon
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8. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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9. The genetics and genomics of familial renal carcinoma
- Prof. Eamonn Maher
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10. Genomics of lung cancer
- Prof. Ramaswamy Govindan
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11. The genetics of glioblastoma
- Dr. Hai Yan
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12. Genetics of tumor metastasis 1
- Prof. Robert Weinberg
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13. Genetics of tumor metastasis 2
- Prof. Robert Weinberg
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14. CML: genetic paradigm of targeted therapy 1
- Prof. Michael W. Deininger
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15. CML: genetic paradigm of targeted therapy 2
- Prof. Michael W. Deininger
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16. The non-coding RNA revolution in the cancer society
- Prof. George Calin
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17. Role of molecular markers in guiding therapy in cancer
- Prof. Joe Duffy
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18. Functional cancer genomics
- Prof. Roderick Beijersbergen
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19. Pharmacogenomics in cancer therapy
- Prof. Sharon Marsh
Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- The cancer challenge
- Genetic risk for cancer
- Genetic risk for cancer - research
- Sword of Damocles
- Taking a cancer family history
- Verify family history
- Dynamics history of family cancer
- When should genetic testing be considered
- Advantages and challenges of tumor surveillance
- Genetic predisposition testing - multiple process
- Hereditary component
- Failure in taking good family history
- Family history collection
- FHx is important
- Adult causes of colon cancer
- Hereditary GI cancer syndromes and genes
- Familial adenomatous polyposis
- FAP clinical manifestations
- FAP surveillance
- Lynch syndrome (HNPCC)
- Lynch syndrome & mismatch repair genes
- Extra colonic cancer
- Management of Lynch syndrome
- Hamartomatous polyposis syndromes
- Peutz-Jeghers syndromes
- PJS & GI\non-GI cancers
- Juvenile polyposis
- Cowden syndrome
- Cowden syndrome - symptoms
- Hereditary breast and ovarian cancer
- Hereditary breast and ovarian cancer BRCA1/2
Topics Covered
- Importance of family history
- Precision medicine
- Genetic predisposition testing
- Advantages and challenges of tumor surveillance
- Hereditary cancer syndromes and genes
- GI cancer syndromes
- Breast and ovarian cancer syndromes
Talk Citation
Schiffman, J. (2016, February 29). Genetics and management of inherited cancer predisposition 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/LNGN9088.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Joshua Schiffman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Genetics and management of inherited cancer predisposition 1
Published on February 29, 2016
25 min
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
JOSHUA SHIFFMAN: Hello.
My name is Joshua Shiffman.
I am a pediatric oncologist
at the University of Utah,
where I take care of patients
with hereditary cancer syndromes
as well as do research in the field.
0:15
Today, we're going to talk about
the importance of family history.
We will cover several of the more
common hereditary cancer syndromes
including, GI cancers, breast
cancers, Li-Fraumeni Syndrome,
Paraganglioma and VHL syndromes.
And finally, we'll end with some
brief discussion about research
in the field of hereditary
cancers specifically
related to comparative oncology.
0:41
Cancer is quite common.
In fact, it is one of the leading
causes of death around the world,
and 15 people will die
from cancer every minute.
Half of all men and
a third of all women
will develop cancer
throughout their lifetime.
This makes the study of
cancer and the risk for cancer
quite relative to disease
and impact on human health.
1:06
In terms of the genetic
risk for cancer,
we believe that as
many as 1 in 10 adults
will have cancer that is caused
to an inherited genetic risk.
This comes to approximately
160,000 new diagnoses per year
for cancer in the US alone.
In terms of childhood
cancer, we believe
that it may be as
high as 1 in 3 children
who have developed cancer
due to an inherited genetic risk.
This comes to approximately 4,500
new diagnoses for cancer per year.