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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- Why the presentation is relevant to this series
- What is a "founder effect"?
- Founder effect: very important concept
- Aim of presentation
- A brief population history
- Where is Qubec?
- Present day occupation of the Qubec territory
- French Canadian settlement 1608-1900
- The French Canadian founder effect
- France vs. British isles immigration
- The "register de la population du Qubec ancient''
- Pioneer immigration according to origin
- Genetic contribution to population development
- Demand for descendants
- Founding immigration during French rule period
- Importance of time of arrival
- Founding immigration during French rule period
- Importance of time of arrival
- The XXth century population vs. its founders
- The BALSAC population register
- Genealogical reconstruction
- Basic characteristics of the genealogical sample
- Completeness of genealogies, per generation
- Identification of subjects with common ancestors
- Founders distribution by origin and marriage period
- Cumulative genetic contribution of founders (%)
- Distribution and genetic contribution of founders
- Genetic contribution of French founders
- The Quebec regional gene pools
- What happened after the British conquest?
- The Saguenay region
- Major Mendelian diseases in Saguenay
- Quebec regional populations
- Inbreeding
- Mean inbreeding coefficients at the 4th generation
- Mean inbreeding coefficients at the 13th generation
- Study of the genetic heritage of Gaspesians
- Colonization of the Gaspe Peninsula
- Place of residence of the Gaspesian subjects
- Kinship calculations
- Kinship within each group of subjects
- Diversity of maternal \ paternal lineages (Gaspesia)
- Maternal lineages among Gaspesians
- Paternal lineages among Gaspesians
- The French-Canadian founder effect impact
- Regional pattern of the French-Canadian gene pool
- Dominant diseases in the French Canadians
- Recessive diseases in French Canadians
- Genetic disorders prevalent in French Canadians
- Diseases with new founder effects in Quebec
- HSAN2 disease
- Identification of few mutations in the same gene
- T14484C Leber optic atrophy mutation in Quebec
- Conclusion
Topics Covered
- Founder effect
- Population history and the French Canadian founder effect
- The contemporary population in relation to its founders
- Regional gene pools: the examples of the Saguenay and the Gaspesie regions
- Regional distribution of disease mutations
Talk Citation
Brais, B., Desjardins, B., Labuda, D., St-Hilaire, M., Tremblay, M. and Vezina, H. (2007, October 1). The genetics of French Canadians [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 28, 2024, from https://hstalks.com/bs/322/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Bernard Brais has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Dr. Bertrand Desjardins has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Damian Labuda has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Dr. Marc St-Hilaire has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Marc Tremblay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Helene Vezina has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The genetics of French Canadians
- Dr. Bernard Brais,
- Dr. Bertrand Desjardins,
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and 4 more
- Dr. Bernard Brais – Universite de Montreal, Canada
- Dr. Bertrand Desjardins – Universite de Montreal, Canada
- Prof. Damian Labuda – Universite de Montreal, Canada
- Dr. Marc St-Hilaire – Universite Laval
- Prof. Marc Tremblay – Universite du Quebec a Chicoutimi, Canada
- Prof. Helene Vezina – Universite du Quebec a Chicoutimi, Canada
Published on October 1, 2007
48 min