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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- Jewish history and genetics
- Jewish roots and diaspora
- Babylonian exile
- Under the Persians
- After the Roman expulsion
- Modern times
- Classification of Jews
- Jewish subgroups
- Genetic diseases
- Population distributions
- Population specificity
- Diseases found in Ashkenazim
- Lysosomal storage diseases (1)
- Lysosomal storage diseases (2)
- Diseases in Ashkenazim - four LSDs
- Genetic drift
- Heterozygote advantage (selection)
- Hemoglobinopathies
- Malaria
- Arguments for selection
- Arguments for drift
- Other diseases affect Ashkenazim
- Other diseases in Ashkenazim
- Comparing diseases by group
- LSDs versus non-LSDs
- Expected patterns
- Geographic disparities
- Ordered frequencies for LSD mutations
- Ordered frequencies for non-LSD mutations
- Mutation frequencies
- Dating mutations
- Number of generations
- Dating of various mutations
- Times of origin
- LSD and non-LSD are similar
- Geographic distributions
- Diseases tested
- Data analyzed
- Geographic categories
- Mutation frequencies for LSDs
- Mutation frequencies for non-LSDs
- Frequency of TSD 1421
- Difference in distribution of LSDs and non-LSDs
- The TSD-1277 mutation distribution
- The TSD-1421 mutation distribution
- The origin of the TSD mutation
- The genetic drift: explanation for these mutations
- Conclusions concerning the AJ LSD mutations
- Bottlenecks in the Jewish population
- Three bottlenecks
- Selection versus drift
Topics Covered
- Jewish history and genetics
- Classification of Jews
- Genetic diseases found in Jews, particularly Ashkenazi Jews
- Lysosomal storage diseases
- Natural selection (heterozygote advantage) vs. genetic drift
- Mutation frequencies, ages and geographic distributions
- Bottlenecks in Jewish history
Talk Citation
Risch, N. (2007, October 1). Genetic diseases in the Jewish population [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/321/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Neil Risch has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.