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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- Genetics of cancer
- Oncogenes
- Tumor suppressor genes
- Breast cancer "family 0"
- The two-hit hypothesis
- How much breast and ovarian cancer is hereditary
- Hereditary susceptibility causes to ovarian cancer
- Hereditary susceptibility causes to breast cancer
- BRCA1 and BRCA2 mutations
- Lifetime cancer risk in mutation carriers
- Epidemiology: BRCA1 and BRCA2
- Founder effect
- Selected examples of founder mutations
- BRCA1 and BRCA2 mutations in Ashkenazi Jews
- Varied penetrance
- New York breast cancer study (NYBCS)
- NYBCS family 96: "low incidence family"
- Family 96: BRCA1 5382insC
- Relatives with BRCA1\2 mutations: breast cancer
- Relatives with BRCA1\2 mutations: ovarian cancer
- Relatives with BRCA1\2 mutations: cancer onset
- Factors affecting penetrance
- Factors not significantly associated with age
- New York breast cancer study conclusions
- Mutation detection for BRCA1 and BRCA2
- Inherited large rearrangements in BRCA1\BRCA2
- Genomic regions of BRCA1 and BRCA2
- Genetics of breast cancer "mystery families"
- Inherited breast and ovarian cancer
- PALB2 1592delT in Finnish breast cancer families
- PALB2 1592delT: Finnish prostrate cancer family
- Genes for inherited breast cancer
- Breast cancer genes and genomic integrity
- Biology of breast cancer genes
- Identification of inherited cancer risk
- Benefits
- Risk assessment
- Cancer risk reduction in women
- Preventive removal of ovaries
- Women with increased-risk family history
Topics Covered
- General cancer genetics
- Tumor suppressor and oncogenes
- Knudson's 'two hit' hypothesis
- Genetic predisposition to breast and ovarian cancer
- How much breast and ovarian cancer is inherited and the causes (genes responsible)
- Cancer risk in populations
- Factors that affect penetrance
- Mutation detection
- Risk reduction and prevention strategies
Links
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Talk Citation
Welcsh, P. (2007, October 1). The genetics of breast and ovarian cancer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/319/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Piri Welcsh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.