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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- The problem
- The limit to resolution of pedigree studies
- Possible solution
- Theory of two loci
- Linkage equilibrium
- Linkage disequilibrium
- Linkage disequilibrium measures
- No recombination: SNPs A and B mutations
- No recombination: only three gametes
- Genealogical interpretation of D'=1
- Statistical significance of LD
- Decay of LD over time
- Linkage disequilibrium change and random drift
- LD and recombination rate equilibrium relation
- Linkage disequilibrium decays across a gene
- Linkage disequilibrium is rare beyond 100 kb or so
- The linkage disequilibrium beyond 500 Kb
- LD means the sites are likely to be close together
- LD patterns examination by testing all sites' pairs
- Different human populations different levels of LD
- The international HapMap project
- LD decay across the genome HapMap
- Heterogeneity of LD across the genome
- Recombination hotspots can break LD blocks
- Hotspots of recombination
- Tag SNPs increase efficiency in studies
- SNPs proportion in phase I HapMap with tag SNP
- Using the HapMap website (1)
- Using the HapMap website (2)
- Using the HapMap website (3)
- Macular degeneration and CFH
- Age-related macular degeneration
- Transformative technology
- Design of GWAS
- Ongoing GWAS studies
- The wellcome trust case control consortium (1)
- The wellcome trust case control consortium (2)
- dbGaP
- Etiology or prediction? Drugs or diagnostics?
- Etiology
- Use of ability to predict disease risk
- One DNA test gets you your perfect vitamin pack
- The future paradigm: the 4 P's
Topics Covered
- The problem in pedigree analysis
- A possible solution for the resolution limitations in pedigree analysis
- Theory of two loci
- Linkage equilibrium and disequilibrium
- Recombination events between SNPs
- Genealogical interpretation
- Statistical significance of LD
- The effect of random drift on linkage disequilibrium
- Variability of LD among different populations
- Heterogeneity of LD across the genome
- Hotspots of recombination
- Tag SNPs
- The HapMap website
- Design of GWAS
- Welcome Trust Case Control Consortium
- Etiology
Talk Citation
Clark, A. (2007, October 1). The HapMap project [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/310/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Andrew Clark has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.