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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- Changes in habitat and life style
- Neutral and selected mutations trajectories
- Selection around polymorphic advantageous allele
- Selection around a fixed advantageous allele
- Distinguishing between demography and selection
- Two types of approaches
- Duffy blood group locus (FY): a case study
- FY*0 occurs at near-fixation frequency in Africa
- FY*0 allele: outlier in the human Fst distribution
- The signature of a selective sweep (1)
- The signature of a selective sweep (2)
- Resequencing survey of the FY region in Africa
- The FY*0 allele is found on two major haplotypes
- Sweeps on standing neutral variation
- Highly differentiated SNPs in the HapMap data
- Detecting signals of local adaptations
- Lactase gene is associated with selection signal
- Distribution of lactase persistence
- Selection on lactase persistence in Africa
- Human skin pigmentation
- Mechanisms of adaptations in pigmentation
- Genes responsible for Mendelian forms of albinism
- Local adaptations at the CYP3A genes
- Re-sequencing survey of the CYP3A gene cluster
- CYP3A5*1/*3 in the HapMap data
- CYP3A variation and sodium retention
- Human genome diversity panel
- Salt sensitivity variants frequency
- Human migrations out of Africa
- Variants affect Na homeostasis vs. random ones
- Hypertension variants are correlated with latitude
- Summary
Topics Covered
- Changes in habit and life style during human evolution
- Evolutionary dynamics of neutral and advantageous mutations
- Signature of natural selection on patterns of variation linked to an advantageous variant
- Distinguishing between demography and natural selection
- Duffy blood group locus
- Lactase persistence
- Skin pigmentation
- Salt sensitivity variants and hypertension
Talk Citation
Di Rienzo, A. (2007, October 1). The signature of local adaptations in human polymorphism data [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/309/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Anna Di Rienzo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.