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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- Definitions
- Nomenclature
- Polymorphism types
- Polymorphisms in human gene pool
- Discovery of microsaellite polymorphisms
- Evidence of polymorphisms in human CA repeats
- Genotyping microsatellite polymorphisms
- Complications of microsatellite analysis
- Non-integer alleles
- Strand slippage
- Instrumentational improvement in genotyping
- Microsatellite genotyping output and cost
- Three basic microsatellite repeats
- Alternative names
- Distribution of STRs in whole human genome
- Diallelic short insertion/deletion polymorphisms
- Abundances of mono- and dinucleotide repeats
- Abundances of tri- and tetranucleotide repeats
- Applications of microsatellites
- Linkage disequilibrium
- STRP pairs showing allelic association
- Geoancestry of subjects from Dominican Republic
- Autozygous detection segments of chromosome 6
- Microsatellite mutation
- Informativeness of (CA)n versus number of repeats
- Microsatellite mutation events
- Distribution - mutation rate vs. repeat length
- Delta values versus repeat length
- Polymorphisms in human gene pool
- Biological function of microsatellites (1)
- Trinucleotide repeat diseases
- Biological function of microsatellites (2)
- Evolution of microsatellites
- A-rich microsatellites from retroposon poly-A tails
- Allele frequency distribution - ACT1A01
- Allele frequency distribution - AFM002zf1
- Human minisatellites
- Canonical minisatellites
Topics Covered
- Microsatellites: nomenclature and definitions
- Discovery
- Typing methodology
- Abundance and types
- Applications
- Mutation
- Biological functions
- Evolution
- Minisatellites
Talk Citation
Weber, J. (2007, October 1). Human microsatellite and minisatellite DNA polymorphisms [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 24, 2024, from https://hstalks.com/bs/307/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. James Weber has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.