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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- The human genome diversity project (HGDP)
- Political difficulties in 1993-4
- The HGDP collection
- Populations included in the HGDP
- Paper obtained with the HGDP-CEPH collection
- Estimated population structure
- Explanation of the method structure
- Basic clusters of the method structure
- F. Blumenbach, the father of anthropology
- Are partitions suggested by structure useful 'races'
- Present limitations of HGDP-CEPH
- Are structure established clusters 'good' races?
- Races might be useful for medicine
- Smaller races
- Correlation of genetic and geographic distance
- Two examples of the correlation
- Drift and migration determine genetic variation
- Drift and natural selection
- Serial founder effect
- Geographic distance vs. expected heterozygosity
- Expansion from E. Africa - founder effects
- Loss of heterozygosity due to founder effect
- Coevolution of genes and languages
- The world's language families
- Families that survived with less important changes
- Linguistic families
- Genetic and linguistic trees
- Darwin's statement
- The complete tree of language evolution
Topics Covered
- The human genome diversity project (HGDP)
- Method structure
- Limitations of HGDP-CEPH
- Are the clusters established by structure "good" races?
- Correlation between genetic and geographic distance
- Decrease of genetic diversity in the human expansion as serial founder effect
- Coevolution of genes and languages
- Linguistic families: correlation of the genetic and linguistic trees
- Darwin's statement
- The complete tree of language evolution
Talk Citation
Cavalli-Sforza, L.L. (2007, October 1). History and geography of human genetic diversity III [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/303/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Luigi Luca Cavalli-Sforza has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.