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- Human Population Genetics: An Overview
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1. Modern human origins
- Prof. Richard Klein
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2. History and geography of human genetic diversity I
- Prof. Luigi Luca Cavalli-Sforza
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3. History and geography of human genetic diversity II
- Prof. Luigi Luca Cavalli-Sforza
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4. Cultural evolution
- Prof. Marcus Feldman
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5. The human genomes
- Prof. Gil McVean
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6. Human population structure
- Prof. Noah Rosenberg
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7. The signature of local adaptations in human polymorphism data
- Dr. Anna Di Rienzo
- The Human Genome Project
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8. The HapMap project
- Prof. Andrew Clark
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9. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
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10. Evolution of human mitochondrial DNA variations
- Prof. Toomas Kivisild
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11. Ethical issues in human population genetics
- Prof. Henry Greely
- Important Phenotypic Phenomena
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12. Evolution: how genes and their variation got here
- Prof. Kenneth Weiss
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13. The genetic component to diabetes
- Dr. Nancy Cox
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14. Genetics of breast and ovarian cancer
- Prof. Jeffrey Weitzel
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15. Colorectal cancer and the rare variant hypothesis
- Prof. Sir Walter Bodmer
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16. Genetic diseases in the Jewish population
- Prof. Neil Risch
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17. The genetics of French Canadians
- Dr. Bernard Brais
- Dr. Bertrand Desjardins
- Prof. Damian Labuda
- Dr. Marc St-Hilaire
- Prof. Marc Tremblay
- Prof. Helene Vezina
- Historical and Geographical Genetic Variation
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18. Human genetic variation of Africa
- Prof. Joanna Mountain
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19. Genetics of Pakistani populations in an Asian and global context
- Prof. S. Qasim Mehdi
- Archived Lectures *These may not cover the latest advances in the field
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20. The genetics of breast and ovarian cancer
- Dr. Piri Welcsh
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21. Historical and geographical genetic variation: Europe
- Prof. Antonio Torroni
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22. Linguistic evolution
- Dr. Merritt Ruhlen
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23. Human microsatellite and minisatellite DNA polymorphisms
- Dr. James Weber
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24. Human population genetics: lifespan
- Prof. Kaare Christensen
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25. History and geography of human genetic diversity III
- Prof. Luigi Luca Cavalli-Sforza
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26. Major gene families in humans and their evolutionary history
- Prof. Yoshihito Niimura
- Prof. Masatoshi Nei
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27. Natural selection and sequence polymorphism
- Prof. Austin Hughes
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28. Human Y chromosome phylogenetics and phylogeography
- Prof. Peter Underhill
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29. The peopling of the Americas: new insights from genetic studies
- Dr. Theodore Schurr
Printable Handouts
Navigable Slide Index
- Introduction
- How do we describe genetic variation?
- Four major factors of evolution: mutation
- Natural selection and drift
- Migration
- Role of demography in the study of evolution
- Calculating selection rate
- Balancing selection
- Drift and population size
- Drift and migration
- Drift, once the Cinderella of evolution
- The aim of the Parma valley study
- Computing expected genetic variation due to drift
- Computer simulation of drift in 22 villages
- Results of the computer simulation
- Equilibrium of migration and drift
- Calculation of drift in larger populations
- Population density and drift in the Parma valley
- Genetic variation plotted against population density
- Simulations of expected effect of drift on variation
- Simulation conclusions
- How fast is fixation or extinction under drift ?
- Founders' effect
- Evolutionary history and present genetic variation
- Prediction of evolutionary history using drift
- Model for evolution reconstruction
- The first application of the model
- Genetic distances based on blood groups (1)
- Genetic distances based on blood groups (2)
- Tree of evolution
- Is drift the only evolutionary factor involved?
- Anthropometric vs. genetic world tree
- Major differences between the two trees
- Conclusions (Cavalli-Sforza and Edwards, 1964)
- Molecular evolution reinforces importance of drift
- Kimura's theorem on molecular evolution (1)
- Kimura's theorem on molecular evolution (2)
- Molecular evolution of proteins
- Rate of molecular evolution varies among proteins
- Trees with proteins, trees with DNA
- An example of philogeographic analysis (1)
- An example of philogeographic analysis (2)
- Microsatellites
- Using microsatellites to define populations
- A tree with 30 microsatellites (1)
- A tree with 30 microsatellites (2)
- Graphic presentation of evolution data by PCA
- Eigenvalues and eigenvectors
- Understanding PCA
- PCA of 21 European populations (1)
- PCA of 21 European populations (2)
- Same European populations analyzed by tree
Topics Covered
- Four major factors of evolution: mutation, natural selection, drift, migration
- Role of demography in the quantitative study of evolution
- Drift: the Parma Valley study
- Equilibrium of migration and drift
- Founders' effect
- Reconstructing evolutionary history of a population
- Evidence of the importance of drift from molecular evolution
- Molecular evolution of proteins
- Trees with proteins and trees with DNA
- Phylogeographic analysis
- Microsatellites
- Graphic presentation of evolution data by principal components analysis
Talk Citation
Cavalli-Sforza, L.L. (2007, October 1). History and geography of human genetic diversity I [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/301/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Luigi Luca Cavalli-Sforza has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
History and geography of human genetic diversity I
Published on October 1, 2007
48 min