Topics Covered
- Endothelial apoptosis
- Role in tumor response to radiation therapy
- Tissue damage results from depletion of stem cells and cells with clonogenic capacity
- Radiation targets the DNA leading to reproductive (mitosis-associated) or apoptotic cell death
- Modifications of DNA damage recognition and repair pathways determine the level of tissue sensitivity to radiation
- Sphingomyelin
- Ceramide
- GI tract and bone marrow: very radiation responsive
- Growth patterns of tumors
- The two-target model for single-dose radiotherapy of experimental tumors
- Engaging the vascular component of tumor response to radiation
Links
Series:
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Therapeutic Areas:
Talk Citation
Kolesnick, R. (2007, October 1). Endothelial cell apoptosis [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 20, 2023, from
https://hstalks.com/bs/296/.
Export Citation (RIS)
Publication History
-
Published on October 1, 2007
Financial Disclosures
- Prof. Richard Kolesnick has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.