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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Topics to cover
- SLE - apoptotic cells clearance deficiency
- Apoptotic cells clearance deficiency - conclusion
- SLE - introduction
- Woman with SLE
- SLE - predispositions
- SLE clinical characteristics
- SLE etiology
- SLE pathology
- Introduction - apoptotic and necrotic cell death
- Apoptosis and necrosis
- Introduction - clearance of dying cells
- Dying cells: source of autoantigens
- Apoptotic cell clearance
- Necrotic cell clearance
- Apoptotic cell
- Process of apoptosis - ligand recognition
- Process of apoptosis - impaired ligand recognition
- Phagocytosis - mediating ligands and receptors
- Apoptosis does not evoke inflammation
- Introduction - anti-inflammatory effects of apoptosis
- Example with monocytes
- AxV reverts anti-inflammation
- AxV reverts humoral immune suppression
- Balance of inflammation
- Balance of inflammation:anti-inflammatory signals
- Secondary necrosis reverses anti-inflammation
- Apoptotic cells in cultured PBMC of SLE patients
- PBMC culture
- Apoptotic cells in germinal centers of SLE patients
- Clearance deficiency in germinal centers (GC)
- Germinal centers of SLE patients
- Clearance deficiency in morphometry - cell count
- Clearance deficiency in morphometry - cell size
- Clearance deficiency in GC: confocal
- B cell maturation - healthy donor
- Apoptosis of mutated B cells - healthy donor
- ANA-reactive B cells - healthy donor
- ANA-reactive B cells - SLE patient
- Apoptotic trash causes autoimmunity
- Apoptotic trash triggers anti-dsDNA reactivity
- Implications for anti-dsDNA
- Binding specificity of 33.C9 variants
- The 33C9 Ab gained its activity in the GC reaction
- High affinity Abs generated in GC
- Apoptotic cells accumulate in CLE skin
- Apoptotic cells accumulate in CLE skin - TUNEL
- Apoptotic cells accumulate in CLE - caspase 3
- Apoptotic cells accumulate in CLE - cell count
- Humoral factors contribute to the clearance
- NHD-derived macrophages trigger cell clearance
- Clearance deficiency in SC derived phagocytes
- Stem cells in culture
- Stem cells cell cycle
- Stem cells phagocytosis and adherence
- Summary stem cells phagocytosis and adherence
- Animal models for clearance deficiency - intro
- Knockout mice with phagocytosis defects
- Conclusion
- Support
- Coworkers
Topics Covered
- Anti-inflammatory and immunosuppressive effects of apoptotic cells
- Autoimmune disease and clearance of dying cells
- Clearance deficiency of apoptotic cells
- Germinal centre tingible body macrophage deficiency
- Model for the generation of nuclear autoimmunity
- Annexin V as adjuvans for irradiated tumor cells
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Herrmann, M. (2007, October 1). Apoptotic cell clearance deficiencies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/295/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Martin Herrmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.