TY - ADVS TI - Evolutionary tradeoffs and the geometry of gene expression space AU - Alon, Uri PY - 2014 DA - 2014/11/04 UR - https://hstalks.com/bs/2938/ AB - Organisms, tissues and molecules often need to perform multiple tasks, Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff, We study this using the concept of Pareto optimality from engineering and economics, Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons, At the vertices of these polygons are phenotypes that specialize at a single task, We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems. DB - The Biomedical & Life Sciences Collection SN - 2056-452X ID - 3787 PB - Henry Stewart Talks ER -