A versatile platform for multilevel modeling of physiological systems

Published on November 4, 2014   33 min

Other Talks in the Category: Methods

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Hello, I’m Yoshiyuki Asai, a group leader of open biology unit in Okinawa Institute of Science and Technology, Japan. In this lecture I want to introduce a versatile platform for multilevel modeling of physiological systems. In recent biological and physiological research, computable mathematical models have
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become increasingly important for integrating the huge amount of knowledge and data obtained from experiments and simulations, and for applying simulation results to medicine. One of dream in such integrative physiology is to cause a paradigm shift from empirical medicine to predictive medicine.
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To promote effective collaborations to build large-scale models, it is also important to consolidate fundamental tools to support such activities. Model sharing and model reuse, which are crucial for the above-mentioned multidisciplinary collaborations, must be encouraged by using such tools. There have been several pioneering efforts to develop technologies in that direction such as SBML, CellML and PHML, among others. These are XML-based descriptive language-formats to describe the dynamics of biological and physiological systems. The main purpose of the development of these languages was to establish a common communication foundation to enhance the exchange of models among collaborators.
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Research in this kind of direction is sometimes referred to as Physiome, which is one of omics such as genome and proteome. It is considered that the first step what must be done in Physiome is to develop comprehensive methods for acquisition and databasing of very large sets of information on all aspects of biology to share and reuse the data among researchers. Then construct descriptive and quantitative models and organize collaborations.
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A versatile platform for multilevel modeling of physiological systems

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