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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- p53 is a tumor suppressor
- Evidence that p53 is a tumor suppressor
- Additional evidence that p53 is a tumor suppressor
- Half of all human cancers carry p53 mutations
- p53 is a sequence-specific transcription factor
- Schematic structure of p53 protein
- Example: the biological activities of p53
- Effect of temperature-sensitive p53 activation
- Induction of cell death by activated p53
- Activated p53 induces apoptosis in leukemic cells
- p53 is activated by oncogenic stress
- p53 is activated by various cellular stress types
- Induction of p53 by DNA damage (cisplatin)
- How is p53 activated?
- Some p53 target genes
- Activity of transcriptional activation-deficient p53
- Translocation of p53 in response to DNA damage
- Transcription activity in response to DNA damage
- Mitochondrially targeted p53
- Mitochondrially targeted p53 induces apoptosis
- Transcriptional activation-deficient and wt p53
- PUMA releases p53 from Bcl-xL
- Integrated apoptotic activities of p53
- How is p53 activity restrained in absence of stress
- MDM2 - a negative regulator of p53
- Basic facts about MDM2
- How does MDM2 inactivate p53?
- MDM2 promotes degradation of p53
- p53 levels determine its fate
- p53-MDM2 negative autoregulatory feedback loop
- Disrupting the p53-MDM2 feedback loop
- p53 in evolution
- p53 transcriptional activity in drosophila embryo
- Effect of dominant negative p53 activity in the fly
- C.elegans p53 is required for germ cell apoptosis
- How is the outcome of p53 activation determined
- p53 activation: growth arrest or cell death?
- Induction of p21 by p53 can inhibit apoptosis
- Some p53 target genes are anti-apoptotic
- p53 mutations lead to different effects on its action
- Mutant p53 overexpression prevents apoptosis
- Mutant p53 protects cancer cells from killing
- Knock-down of mutant p53 restores killing
- Mutant p53 down-regulates surface CD95 protein
- Mutant p53 down-regulates the CD95 promoter
- p53-based cancer therapy
- p53-MDM2 binding
- Drugs that disrupt p53-mdm2 binding - Nutlin
- Nutlin induces p53 activation/ tumor regression
- PRIMA-1 affects mutant p53
- PRIMA-1 synergizes with cisplatin
- Summary
Topics Covered
- p53 as a tumor suppressor
- Regulation of transcription by p53
- Activation of p53 by oncogenic stress
- Transcriptional and non-transcriptional mechanisms for p53- mediated apoptosis
- Regulation of p53 by Mdm2
- Evolutionary conservation of p53 function
- Mutant p53 gain of function
- p53-based cancer therapy
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Oren, M. (2007, October 1). p53 and apoptosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/291/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Moshe Oren has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.