• Evolution of the Apoptotic Pathway
• 52 min
  1. Apoptosis in C. elegans

  • Prof. Michael Hengartner
• 46 min
  2. Regulation of apoptosis: lessons from Drosophila and their implications for human health and disease

  • Prof. Hermann Steller
• The Apoptotic Pathway in Humans
• 29 min
  3. The death receptor signalling pathway

  • Dr. Richard Siegel
• 36 min
  4. Mitochondria and apoptosis

  • Prof. Stephen Tait
• Apoptosis Molecules
• 24 min
  5. The Bcl-2 family

  • Dr. David Huang
• 43 min
  6. Caspases

  • Prof. Yuri Lazebnik
• 37 min
  7. Natural caspase inhibitors

  • Prof. Guy Salvesen
• 44 min
  8. Mechanisms of apoptosis from structural biology

  • Prof. Yigong Shi
• 27 min
  9. TRAIL-induced apoptosis: from analysis of the death-inducing signalling complex (DISC) to clinical applicability

  • Dr. Henning Walczak
• Clearance of Apoptotic Cells
• 28 min
  10. Phagocytosis of apoptotic cells

  • Prof. Peter Henson
• Non-Apoptotic Cell Death Programs
• 34 min
  11. Autophagic cell death

  • Prof. Eric Baehrecke
• Apoptosis and Disease
• 64 min
  12. p53 and apoptosis

  • Prof. Moshe Oren
• 47 min
  13. The p53 family: function and molecular mechanisms

  • Prof. Gerry Melino
• 62 min
  14. Apoptosis in the immune system

  • Prof. Peter Krammer
• 68 min
  15. Apoptosis in the nervous system

  • Prof. Pierluigi Nicotera
• Clinical Application of Apoptosis Research
• 49 min
  16. Endothelial cell apoptosis

  • Prof. Richard Kolesnick
• 31 min
  17. Targeting apoptosis pathways in cancer therapy

  • Dr. Simone Fulda
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  18. Targeting apoptosis pathways in cancer therapy

  • Dr. Irene Ghobrial
• 20 min
  19. Apoptotic pathways in mammals

  • Prof. Douglas Green
• 46 min
  20. Lysosomal cell death pathways: new possibilities for cancer therapy

  • Prof. Marja Jaattela
• 57 min
  21. Degradation of apoptotic cells

  • Prof. Shigekazu Nagata
• 61 min
  22. Signaling during engulfment: the beginnings of a good meal

  • Prof. Kodi Ravichandran
• 29 min
  23. Apoptotic cell clearance deficiencies

  • Prof. Martin Herrmann
• 46 min
  24. Caspase inhibitors in drug discovery

  • Dr. Tom O'Brien
• 28 min
  25. Mitochondria in apoptosis

  • Prof. Jean-Claude Martinou

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Fas ligand-induced cell death
3. Apoptosis-video
4. Activation of caspase
5. Signal transduction for Fas-mediated apoptosis
6. Apoptotic DNA fragmentation
7. CAD-mediated DNA degradation
8. Tertiary structure of CAD
9. No apoptotic DNA degradation in CAD-null cells
10. Apoptosis without DNA fragmentation
11. Multiple ways for caspase-mediated cell death
12. TUNEL-staining in vivo without CAD
13. Engulfment of apoptotic cells by macrophage
14. Two systems for apoptotic DNA degradation
15. Death of DNase II-null embryos in feto
16. Accumulation of undigested CAD-null nuclei
17. Accumulation of undigested nuclei in thymus
18. Long and intact DNA in lysosomes
19. Impaired thymic development in mutants
20. Induction of IFN-inducible genes
21. Induction of interferon beta gene
22. Rescue of the lethality of DNase II-null embryos
23. TLR mediated activation of IFNbeta gene
24. Non-involvement of TLRs system
25. Apoptosis and phagocytosis
26. Molecules for engulfment of apoptotic cells
27. Video - engulfment by a macrophage
28. Engulfment assay using CAD-/- cells
29. TUNEL assay for phagocytosis
30. Milk fat globule EGF factor 8
31. Binding of MFG-E8 and Del-1 to apoptotic cells
32. What is recognized by MFG-E8 and Del-1?
33. Specific binding MFG-E8 and Del-1 to PS
34. MFG-E8 and Del-1 work as a bridge
35. MFG-E8/Del-1-mediated engulfment
36. Expression of MFG-E8 in macrophages
37. Tingible-body macrophages
38. Inefficient engulfment of apoptotic cells
39. Inefficient ingestion of apoptotic cells
40. Splenomegaly in MFG-E8-deficient mice
41. Production of autoantibodies in MFG-E8-/- mice
42. Accumulation of immune complex
43. Model for the autoantibody production
44. Conclusions
45. Summary

Topics Covered

• Apoptosis
• DNA fragmentation during apoptosis
• DNA degradation in macrophages
• Activation of innate immunity by undigested DNA
• Engulfment of apoptotic cells
• Phosphatidylserine-dependent engulfment of apoptotic cells
• Autoimmune disease caused by unengulfed apoptotic cells

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Shigekazu Nagata has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.