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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Limited proteolysis vs. degradation
- Regulation of proteolytic activity (1)
- Regulation of proteolytic activity (2)
- Apoptotic pathway
- Caspase structure (1)
- Caspase structure (2)
- Caspase structure - the active site
- Caspase structure - zooming in the active site
- Caspase zymogen activation
- Monomer/dimer status of caspase zymogens
- Initiator and executioner caspases
- Natural caspase inhibitors
- CrmA
- Selectivity of CrmA
- p35
- Selectivity of p35
- p35 docks into active site of caspases
- CrmA and caspases active site
- Viral "suicide" caspase inhibitors
- IAPs - the endogenous caspase regulators
- Human IAPs (BIRC 1-8)
- Some other IAPs
- Mouse IAPs knockout phenotypes
- Multiple proposed IAP functions
- The BIR domain (1)
- The BIR domain (2)
- IAPs as caspase inhibitors - XIAP, the paradigm
- Domain organization of XIAP
- Caspase 3/BIR2 complex
- Structure of caspase 3/DEVD-CHO
- Structure of the caspase 3/BIR2 complex
- Inhibitor footprints and the role of the 381 loop
- Caspase-3 bound state
- Caspase-3 free state
- Two site interaction hypothesis
- BIR2 mechanism
- Comparison of XIAP-BIR complexes
- BIR3 mechanism
- XIAP inhibition of caspases
- Caspase activation vs. IAP derepression
- The SMAC groove...competition of IBMs
- IBMs
- SMAC mechanism - caspase 9/BIR3
- BIR domain topology
- BIR2 domain comparisons - the SMAC groove
- BIR2 domain comparisons - the N-terminal linker
- BIR3 domain comparisons - the SMAC groove
- BIR2 domain comparisons - the C-terminal helix
- Variations in N-terminal linker or C-terminal helix
- Human IAPs (BIRC 1-8)
- What about the other 7 human IAPs?
- Acknowledgements
- Representative reviews
Topics Covered
- Apoptosis
- Proteolytic mechanisms
- Caspases
- Activation mechanisms
- Natural caspase inhibitors
- Viral inhibitors
- IAPs
- Inhibitory mechanisms
- IAP antagonists
- Theory of activating apoptosis by de-repression of caspase inhibition
Talk Citation
Salvesen, G. (2007, October 1). Natural caspase inhibitors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/283/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Guy Salvesen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.