• Evolution of the Apoptotic Pathway
• 52 min
  1. Apoptosis in C. elegans

  • Prof. Michael Hengartner
• 46 min
  2. Regulation of apoptosis: lessons from Drosophila and their implications for human health and disease

  • Prof. Hermann Steller
• The Apoptotic Pathway in Humans
• 29 min
  3. The death receptor signalling pathway

  • Dr. Richard Siegel
• 36 min
  4. Mitochondria and apoptosis

  • Prof. Stephen Tait
• Apoptosis Molecules
• 24 min
  5. The Bcl-2 family

  • Dr. David Huang
• 43 min
  6. Caspases

  • Prof. Yuri Lazebnik
• 37 min
  7. Natural caspase inhibitors

  • Prof. Guy Salvesen
• 44 min
  8. Mechanisms of apoptosis from structural biology

  • Prof. Yigong Shi
• 27 min
  9. TRAIL-induced apoptosis: from analysis of the death-inducing signalling complex (DISC) to clinical applicability

  • Dr. Henning Walczak
• Clearance of Apoptotic Cells
• 28 min
  10. Phagocytosis of apoptotic cells

  • Prof. Peter Henson
• Non-Apoptotic Cell Death Programs
• 34 min
  11. Autophagic cell death

  • Prof. Eric Baehrecke
• Apoptosis and Disease
• 64 min
  12. p53 and apoptosis

  • Prof. Moshe Oren
• 47 min
  13. The p53 family: function and molecular mechanisms

  • Prof. Gerry Melino
• 62 min
  14. Apoptosis in the immune system

  • Prof. Peter Krammer
• 68 min
  15. Apoptosis in the nervous system

  • Prof. Pierluigi Nicotera
• Clinical Application of Apoptosis Research
• 49 min
  16. Endothelial cell apoptosis

  • Prof. Richard Kolesnick
• 31 min
  17. Targeting apoptosis pathways in cancer therapy

  • Dr. Simone Fulda
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  18. Targeting apoptosis pathways in cancer therapy

  • Dr. Irene Ghobrial
• 20 min
  19. Apoptotic pathways in mammals

  • Prof. Douglas Green
• 46 min
  20. Lysosomal cell death pathways: new possibilities for cancer therapy

  • Prof. Marja Jaattela
• 57 min
  21. Degradation of apoptotic cells

  • Prof. Shigekazu Nagata
• 61 min
  22. Signaling during engulfment: the beginnings of a good meal

  • Prof. Kodi Ravichandran
• 29 min
  23. Apoptotic cell clearance deficiencies

  • Prof. Martin Herrmann
• 46 min
  24. Caspase inhibitors in drug discovery

  • Dr. Tom O'Brien
• 28 min
  25. Mitochondria in apoptosis

  • Prof. Jean-Claude Martinou

Printable Handouts

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Navigable Slide Index

1. Introduction
2. C.elegans is simple, yet sophisticated (1)
3. C.elegans is simple, yet sophisticated (2)
4. Nobel prize 02' was awarded to 3 worm workers (1)
5. C.elegans hermaphrodite cell lineage
6. Apoptosis in C.elegans (1)
7. C.elegans embryonic development
8. Time course of P11.aap death (Nomarski optics)
9. Nobel prize 02' was awarded to 3 worm workers (2)
10. C.elegans genetic programmed cell death
11. C.elegans ced-3, ced-4 and ced-9 genes (1)
12. Programmed cell death in the pharynx
13. C.elegans ced-3, ced-4 and ced-9 genes ( 2)
14. Activation of cell death machinery in C.elegans (1)
15. Activation of cell death: C.elegans vs. mammals
16. Mitochondria fragment during apoptosis
17. Activation of cell death machinery in C.elegans (2)
18. How does apoptosome activation regulated?
19. Cell death activation via EGL-1 regulation
20. Mutations in ces genes
21. ces (cell death specification) genes
22. ces genes mode of action model
23. ces-1 and ces-2 encode transcription factors
24. Conserved transcriptional regulation of apoptosis?
25. Summary: apoptosis regulation in C.elegans
26. Apoptosis in C.elegans ( 2)
27. The adult C.elegans hermaphrodite germ cell line
28. DNA damage induces germ cell apoptosis
29. Radiation-induced germ cell apoptosis
30. Effect of ced-9 (gf) or egl-1 (lf) on apopatosis (1)
31. Transcriptional control of EGL-1 expression
32. egl-1 mRNA levels increase following irradiation
33. C.elegans p53 homolog: CEP-1
34. A model for C.elegans DNA damage response (1)
35. C.elegans checkpoint genes (1)
36. A model for C.elegans DNA damage response (2)
37. Simplified yeast DNA damage checkpoint pathway
38. HUS1:GFP relocalizes to foci after DNA damage
39. Hus1/rad-9 pathway is conserved through evolution
40. A model for C.elegans DNA damage response (3)
41. C.elegans checkpoint genes (2)
42. C.elegans rad-5/clk-2 genes
43. Summary: DNA damage response pathway
44. The evolution of DNA damage response
45. Effect of ced-9 (gf) or egl-1 (lf) on apopatosis (2)
46. Effect of gla-3 (lf) on germ cell apoptosis
47. GLA-3 is a candidate RNA-binding-protein
48. GLA-3 interacts with MPK-1
49. GLA-3 binds to effector docking site of MPK-1
50. Ras-MAPK pathway is required to exit mitosis
51. Ras-MAPK as a transient developmental stage
52. EGF signaling pathway in C.elegans
53. Genetic pathway for programmed cell death (1)
54. Mutations in engulfment genes (1)
55. Mutations in engulfment genes (2)
56. Recognition and removal of apoptotic cells
57. Genetic pathway for programmed cell death (2)

Topics Covered

• Programmed cell death in C. elegans during development and adulthood
• Differentiation
• The genetic pathway for programmed cell death
• ced-3, ced-4 and ced-9
• Activation of the cell death machinery during C. elegans development and in C. elegans vs. mammals
• How does C. elegans regulate activation of the apoptosome?
• Cell death specification (ces) genes
• NSM sister cell death
• Transcription factors
• A model for C. elegans DNA damage response
• gla-3
• A molecular model for the recognition and removal of apoptotic cells in C. elegans

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Michael Hengartner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.