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TRP channels with diverse permeability profiles: regulation of blood pressure and fertility
Published on February 4, 2014 35 min
A selection of talks on Reproduction & Development
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- Prof. Robb Krumlauf
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I am professor Marc Friechel. I'm working at the Pharmacological Institute, and I'm heading the Department of General Pharmacology. Welcome to my talk with the title, TRP Channels with Diverse Permeability Profiles: Regulation of Blood Pressure and Fertility.
The TRP class of ion channels consists of 6 sub-families, which cover altogether 28 members, at least in mice. Each TRP protein consists of six putative transmembrane domains, and it is generally believed that four of such TRP proteins together form hetero or homomultimeric channel complexes.
Most TRP channels are non selective with a permeability for calcium of a sodium below 10. Therefore TRP channels are not only important for calcium entry across the plasma membrane, but play also an important role in electrogenesis, regulating the driving force for calcium entry via other calcium permeable channels. This table gives you an overview about the permeability of channels formed by individual TRP proteins of the TRPC, TRPV, and TRPM sub-family. It should be emphasized that most of this information is based on studies of heterologously expressed channel proteins. And that characteristics of those channels may differ significantly from native channel complexes that exist in primary cells, since the ectopically expressed channel proteins do not necessarily act in accordance with the native cellular context as in primary sets. Within the TRP family of cation channels the highlighted channel proteins TRPV5 and TRPV6, as well as TRPM4 and TRPM5, have distinct characteristic features. TRPV6 proteins for instance, are able to form channels that conduct calcium ions with the selectivity of calcium over sodium of about more than 100. Whereas TRPM4 protein similar like TRPM5 from cation channels that selectively conduct monovalent cations.