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0:00
Hello.
My name is Alex Costa.
I am a plant biologist and
I work at University of Milan in the
Department of Biosciences, together with
Paola Pizzo from University of Padua
department of biomedical sciences.
We will talk about peroxisomes and
golgi apparatus as players
in calcium homeostasis.
0:22
Peroxisomes are organelles present
in almost all eukaryotic cells.
They are enclosed by a single
lipid bilayer membrane and
inside the peroxisomal lumen,
more than 50 enzymes have been discovered.
This enzymes play roles in different
metabolic pathways, including fatty acid,
beta oxidation, scavenging of hydrogen
peroxide, synthesis of etherphospholipids.
Peroxisomes are numerous and
dispersed throughout the entire cytosol.
And their size and
number is regulated by a specific
transcription factor in mammalian cells.
Peroxisomal membrane is impermeable to
high molecular weight molecules, and for
this reason, specific carriers
are expressed in the organelles for
taking up different metabolites.
1:20
Peroxisome activity has been linked
with many different processes.
For example,
the peroxisomes have emerged as organelles
important in determining cell fate.
The activity has been related to
cell differentiation processes,
embryo development and morphogenesis.
Moreover, impairment of peroxisomal
activity or biogenesis is linked
to different genetic disorders in humans
such as Zellweger syndrome spectrum.
