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- The OECD Principles of GLP
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26 min
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17 min
2. Scope and application- Mr. David Long
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19 min
3. Performing test systems and test items- Prof. Sergio Caroli
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30 min
4. Why OECD GLP and not ISO / IEC 17025?- Dr. Helen Liddy
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29 min
5. Principles of GLP- Mr. David Long
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30 min
6. Performing: standard operating procedures- Mrs. Katariina Rautalahti
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25 min
7. GLP: planning, recording, and archiving- Mr. Phil Withers
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53 min
8. Reporting of study results- Mr. Hedwig Beernaert
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16 min
9. Quality assurance- Mr. David Long
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43 min
10. Facilities: buildings and equipment- Mr. Hedwig Beernaert
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46 min
11. Multi-site studies and field studies- Dr. Geetha Rajashekhar
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18 min
12. In vitro studies and short term studies- Prof. Sergio Caroli
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40 min
13. Computers in a GLP environment- Mr. John McNamee
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23 min
14. The application of the GLP principles in analytical chemistry- Prof. Sergio Caroli
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21 min
15. Good laboratory practice: roles and responsibilities- Mr. David Long
- Monitoring GLP Compliance
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31 min
16. Monitoring GLP compliance: history and OECD framework- Mr. Richard Sigman
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35 min
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30 min
18. Inspection procedures- Mr. Theo Helder
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38 min
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24 min
20. GLP in the European Union- Mr. Maik Schmahl
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42 min
- International Data Acceptance Through OECD
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28 min
22. International data acceptance through OECD: history and OECD context- Mr. Richard Sigman
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17 min
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9 min
24. Participation of non-OECD economies in the MAD system- Ms. Christinah Leballo
Printable Handouts
Navigable Slide Index
- Introduction
- Introductory comments
- Standard operating procedures
- Maintenance
- Equipment failure
- Only a small number of instruments are critical
- Reliability-centred maintenance
- GLP inspector should check all SOPs available
- Stick to the GLP principles!
- Major types of technical equipment
- General-purpose devices
- Physical-chemical apparatuses
- Analytical instrumentation
- Examples of analytical techniques
- Scheme of an LC-ICP-MS system, example 1
- Scheme of an LC-ICP-MS system, example 2
- Scheme of an LC-ICP-MS system, example 3
- Inspector need to assess use & maintenance
- Scope of method validation
- Validation refers to analytical systems
- Each system has a specific field of application
- Validation procedures
- Method performance characteristics
- System validation and GLP inspections
- Check-list of validation items
- Inspector should ask for documented evidence
- The ultimate goal of validation
- Suitability of equipment
- Concentrate on aspects where errors are greatest
- Method development, optimization, validation
- Inspector must check validated methods in place
- GLP validation is more expensive
- Validity depends on reliability of information
- Technical personnel
- The TFM
- The policy of the TFM
Topics Covered
- Analytical chemistry
- Calibration of analytical equipment
- Failure of equipment
- Hyphenated analytical techniques
- Inspections of Good Laboratory Practice-compliant test facilities
- Integrity of studies
- Maintenance of analytical equipment
- Physical-chemical apparatuses
- Principles of Good Laboratory Practice
- Standard Operating Procedures
- Validation of analytical systems
Talk Citation
Caroli, S. (2013, July 18). The application of the GLP principles in analytical chemistry [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 16, 2024, from https://hstalks.com/bs/2593/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Sergio Caroli has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The application of the GLP principles in analytical chemistry
Published on July 18, 2013
23 min
