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Printable Handouts
Navigable Slide Index
- Introduction
- RNA viruses of the orthomyxoviridae family
- Influenza virus structure and nomenclature
- Origins of the word influenza
- Historical writings on influenza
- The 1918-19 pandemic
- History of human pandemics
- Pandemic vs. seasonal influenza (1)
- Pandemic vs. seasonal influenza (2)
- Influenza A in the animal kingdom
- Definition of pandemic influenza
- Antigenic drift
- Antigenic shift
- Pandemic mode 1
- Pandemic mode 3
- Genetic adaptation - pandemic mode 2
- Characteristics of influenza pandemics
- UK pandemic waves in 1918-19
- Mortality in America and Europe: 1918 - 1919
- Age-specific impact (1918)
- Age-specific impact (2009)
- Variation in pandemic severity
- Clinical attack rates
- Summary
- Further reading
- Concluding remarks
Topics Covered
- Classification, structure and nomenclature
- The history of influenza
- The history of human pandemics and recent pandemic threats
- Pandemic versus seasonal influenza
- Antigen recycling
- Relation between animal and human influenza
- Antigen shift
- Modes of pandemic emergence
- Characteristics of human pandemics
- Summary
- Further reading
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Van-Tam, J. (2013, July 11). The making of an influenza pandemic [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/SAHV1180.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jonathan Van-Tam, Grant/Research Support (Principal Investigator): GlaxoSmithKline, F. Hoffmann La-Roche.
A selection of talks on Respiratory Diseases
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, I'm Jonathan Van-Tam from the University of Nottingham,
and welcome to this lecture called The Making of an Influenza Pandemic.
What I'm going to do in the next few minutes is try and
show you the basics of influenza and how we
get these phenomena called pandemics that are created
that are such serious threats to public health.
I'm going to take you from the very basics, through to some more complicated concepts,
and hopefully by the end of the lecture,
you'll have a fairly good grounding in how influenza pandemics occur in nature.
0:41
Let's begin with the influenza virus itself.
On the left, you've got an electron micrograph picture,
and on the right you have some bullet points,
which I shall go through.
The first point I want to make is that influenza viruses are
part of the Orthomyxoviridae family and they are RNA viruses.
The important thing about an RNA virus is that when it replicates,
it doesn't really check itself very well when it's making
multiple copies and it has a high error rate,
the consequence of that in nature is that
there are frequent mutations to the virus.
This will be important when we're thinking about influenza and how it changes,
just store that one away and we'll come back to it.
The next thing to say about influenza is that we
describe three types of virus in nature,
type A, type B, and type C.
Now we do know that types A and B are
the major human pathogens and they're the viruses that give
rise to normal winter epidemics of influenza year on year,
and flu A is particular in being the one that we attribute with causing pandemics.
It's not really possible for influenza B to cause a pandemic,
but Influenza A does and will continue to cause pandemics as we go through human history.
I'll come back to that again a little later.
But the final point on this slide relates to influenza C.
It is an influenza virus, but it is just one of
the 300 or so viruses that together give us the syndrome we recognise as the common cold.
What I'm trying to say is that influenza C is not really influenza
in quite the same sense as influenza A and influenza B,
and in public health terms, it's really not significant.
It's just one of those viruses that causes the common cold, and so in a sense,
and certainly for the rest of this lecture,
it can be set aside and forgotten about.
Now, before we leave this slide altogether,
just look again at the picture and you can see I've put
a red circle on it and if you look inside the red circle,
you can see some spikes sticking out from the surface of the virus.
In the next slide,
we'll look at a diagram and have a little drill down about what those spikes are.
What is their significance?