Interleukin-17: from clone to clinic
24 min
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25 min
1. Mononuclear phagocytes - origins, fates and functions- Prof. Steffen Jung
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39 min
2. Transcription factors in macrophage differentiation- Dr. Michael Sieweke
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44 min
3. Fetal macrophages- Prof. Paul Martin
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44 min
4. The alveolar macrophage- Dr. Ronald G. Crystal
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35 min
5. Airway macrophages in health and disease- Prof. Tracy Hussell
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65 min
6. Intestinal macrophages - heterogeneity, origins and functions- Prof. Allan Mowat
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27 min
7. Osteoclasts: what do they do and how do they do it?- Prof. Steven L. Teitelbaum
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51 min
8. The biology of Fc receptors and complement receptors- Prof. Steven Greenberg
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71 min
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38 min
10. Tumour-associated macrophages- Prof. Michele De Palma
- Dr. Mario Squadrito
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42 min
11. The recognition of pathogens by C-type lectins- Prof. Gordon Brown
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34 min
12. Macrophage phagocytosis- Prof. Joel Swanson
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30 min
13. Macrophage CD36 and atherosclerosis- Dr. Maria Febbraio
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31 min
14. Toll-Like receptor signaling and the innate immune response- Dr. Kate Fitzgerald
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43 min
15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria- Prof. Ricardo Gazzinelli
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34 min
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69 min
17. Triggering receptors expressed on myeloid cells (TREM)- Dr. Daniel W. McVicar
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60 min
18. Influence of eicosanoid lipid mediators on macrophage innate immune functions- Prof. Marc Peters-Golden
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47 min
19. Macrophage paired receptor interactions- Prof. Neil Barclay
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45 min
20. Macrophage heterogeneity in atherosclerosis regression- Prof. Edward Fisher
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35 min
21. Gaucher disease: from lysosomal storage to immunopathology- Prof. Johannes M.F.G. Aerts
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26 min
22. Macrophage in asthma- Prof. Douglas Robinson
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51 min
23. The macrophage mannose receptor- Dr. Luisa Martinez-Pomares
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49 min
24. Immunosuppressive mechanisms in myeloid cells- Prof. Dmitry Gabrilovich
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29 min
25. EGF-TM7 receptors- Dr. Jörg Hamann
- Dr. Hsi-Hsien Lin
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37 min
26. Macrophages in helminth infection- Prof. Judith Allen
Printable Handouts
Navigable Slide Index
- Introduction
- The existing dogma
- Our working paradigm
- Protective autoimmunity
- The CNS immune enigma
- CNS response to injury
- A matter of interpretation
- Recruitment of macrophages is insufficient
- Site, dose, timing for macrophage implantation
- Emerging questions
- Local and systemic immune response
- Circulating T cells are needed for recovery
- Protective autoimmunity vs. autoimmune disease
- Key questions
- The two faces of macrophages
- Creation of chimeric mice with head protection
- Macrophages play anti-inflammatory role
- Transferred monocytes promote repair
- The infiltrated macrophages are beneficial
- T-cells boost monocyte recruitment
- Macrophages resolve microglia response
- Is the location of the macrophages important?
- The glial scar regulates microglia / macrophages
- CSPG production and degradation
- CSPG and the IL-10 expressing monocytes
- Loss of IL-10 in the absence of CSPG
- Macrophages are 'educated' by the scar
- Co-localization of macrophages with the glial scar
- Location determines macrophage phenotype
- Functional distinction between cells
- Are macrophages involved in neuroprotection?
- Macrophages and neuroprotection in the retina
- Macrophages support cell survival in retina
- Macrophages support progenitor cell renewal
- Interim conclusions
- Why monocyte recruitment is limited?
- Type, phenotype, location, timing
- Tissue repair is very demanding
- Neurogenesis: highest manifestation of plasticity
- CNS specific autoreactive T cells
- Spatial memory
- What is the immunological malfunction?
- Immunity to self and self-maintenance
- Local and systemic inflammation
- Circulating cells fight local inflammation
- Recruitment of monocytes in Alzheimer
- Take home message (1)
- Take home message (2)
- From immune deficiency to brain malfunction
- Immune cells are the nectar...
- Acknowledgements
- Financial support
- Conclusions
Topics Covered
- The CNS immune enigma
- CNS response to injury
- Recruitment of macrophages is insufficient
- Site, dose, timing for macrophage implantation
- Local and systemic immune response
- Circulating T cells are needed for recovery
- Protective autoimmunity vs. autoimmune disease
- Two faces of macrophages
- Creation of chimeric mice with head protection
- Macrophages play anti-inflammatory role
- Transferred monocytes promote repair
- T-cells boost monocyte recruitment
- Macrophages resolve microglia response
- The glial scar regulates microglia / macrophages
- CSPG production and degradation
- CSPG and the IL-10 expressing monocytes
- Co-localization of macrophages with the glial scar
- Location determines macrophage phenotype
- Macrophages and neuroprotection in the retina
- Macrophages support progenitor cell renewal
- Monocyte recruitment is limited
- Type, phenotype, location, timing
- Neurogenesis: highest manifestation of plasticity
- CNS specific autoreactive T cells
- Spatial memory
- The immunological malfunction
- Immunity to self and self-maintenance
- Local and systemic inflammation
- Circulating cells fight local inflammation
- Recruitment of monocytes in Alzheimer
- From immune deficiency to brain malfunction
Links
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Talk Citation
Schwartz, M. (2013, January 30). A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 26, 2023, from https://hstalks.com/bs/2481/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Michal Schwartz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair
Published on January 30, 2013
71 min
A selection of talks on Immunology & Inflammation
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