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1. Mononuclear phagocytes - origins, fates and functions
- Prof. Steffen Jung
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2. Transcription factors in macrophage differentiation
- Dr. Michael Sieweke
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3. Fetal macrophages
- Prof. Paul Martin
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4. The alveolar macrophage
- Dr. Ronald G. Crystal
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5. Airway macrophages in health and disease
- Prof. Tracy Hussell
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6. Intestinal macrophages - heterogeneity, origins and functions
- Prof. Allan Mowat
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7. Osteoclasts: what do they do and how do they do it?
- Prof. Steven L. Teitelbaum
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8. The biology of Fc receptors and complement receptors
- Prof. Steven Greenberg
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10. Tumour-associated macrophages
- Prof. Michele De Palma
- Dr. Mario Squadrito
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11. The recognition of pathogens by C-type lectins
- Prof. Gordon D. Brown
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12. Macrophage phagocytosis
- Prof. Joel Swanson
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13. Macrophage CD36 and atherosclerosis
- Dr. Maria Febbraio
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14. Toll-Like receptor signaling and the innate immune response
- Dr. Kate Fitzgerald
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15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria
- Prof. Ricardo Gazzinelli
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17. Triggering receptors expressed on myeloid cells (TREM)
- Dr. Daniel W. McVicar
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18. Influence of eicosanoid lipid mediators on macrophage innate immune functions
- Prof. Marc Peters-Golden
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19. Macrophage paired receptor interactions
- Prof. Neil Barclay
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20. Macrophage heterogeneity in atherosclerosis regression
- Prof. Edward Fisher
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21. Gaucher disease: from lysosomal storage to immunopathology
- Prof. Johannes M.F.G. Aerts
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22. Macrophage in asthma
- Prof. Douglas Robinson
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23. The macrophage mannose receptor
- Dr. Luisa Martinez-Pomares
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24. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
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25. EGF-TM7 receptors
- Dr. Jörg Hamann
- Dr. Hsi-Hsien Lin
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26. Macrophages in helminth infection
- Prof. Judith Allen
- Archived Lectures *These may not cover the latest advances in the field
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27. Immunosuppressive mechanisms in myeloid cells
- Prof. Dmitry Gabrilovich
Printable Handouts
Navigable Slide Index
- Introduction
- The existing dogma
- Our working paradigm
- Protective autoimmunity
- The CNS immune enigma
- CNS response to injury
- A matter of interpretation
- Recruitment of macrophages is insufficient
- Site, dose, timing for macrophage implantation
- Emerging questions
- Local and systemic immune response
- Circulating T cells are needed for recovery
- Protective autoimmunity vs. autoimmune disease
- Key questions
- The two faces of macrophages
- Creation of chimeric mice with head protection
- Macrophages play anti-inflammatory role
- Transferred monocytes promote repair
- The infiltrated macrophages are beneficial
- T-cells boost monocyte recruitment
- Macrophages resolve microglia response
- Is the location of the macrophages important?
- The glial scar regulates microglia / macrophages
- CSPG production and degradation
- CSPG and the IL-10 expressing monocytes
- Loss of IL-10 in the absence of CSPG
- Macrophages are 'educated' by the scar
- Co-localization of macrophages with the glial scar
- Location determines macrophage phenotype
- Functional distinction between cells
- Are macrophages involved in neuroprotection?
- Macrophages and neuroprotection in the retina
- Macrophages support cell survival in retina
- Macrophages support progenitor cell renewal
- Interim conclusions
- Why monocyte recruitment is limited?
- Type, phenotype, location, timing
- Tissue repair is very demanding
- Neurogenesis: highest manifestation of plasticity
- CNS specific autoreactive T cells
- Spatial memory
- What is the immunological malfunction?
- Immunity to self and self-maintenance
- Local and systemic inflammation
- Circulating cells fight local inflammation
- Recruitment of monocytes in Alzheimer
- Take home message (1)
- Take home message (2)
- From immune deficiency to brain malfunction
- Immune cells are the nectar...
- Acknowledgements
- Financial support
- Conclusions
Topics Covered
- The CNS immune enigma
- CNS response to injury
- Recruitment of macrophages is insufficient
- Site, dose, timing for macrophage implantation
- Local and systemic immune response
- Circulating T cells are needed for recovery
- Protective autoimmunity vs. autoimmune disease
- Two faces of macrophages
- Creation of chimeric mice with head protection
- Macrophages play anti-inflammatory role
- Transferred monocytes promote repair
- T-cells boost monocyte recruitment
- Macrophages resolve microglia response
- The glial scar regulates microglia / macrophages
- CSPG production and degradation
- CSPG and the IL-10 expressing monocytes
- Co-localization of macrophages with the glial scar
- Location determines macrophage phenotype
- Macrophages and neuroprotection in the retina
- Macrophages support progenitor cell renewal
- Monocyte recruitment is limited
- Type, phenotype, location, timing
- Neurogenesis: highest manifestation of plasticity
- CNS specific autoreactive T cells
- Spatial memory
- The immunological malfunction
- Immunity to self and self-maintenance
- Local and systemic inflammation
- Circulating cells fight local inflammation
- Recruitment of monocytes in Alzheimer
- From immune deficiency to brain malfunction
Links
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Talk Citation
Schwartz, M. (2013, January 30). A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/UVOG1702.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Michal Schwartz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A paradigm shift in the brain-immune relationships: infiltrating macrophages in central nervous system repair
Published on January 30, 2013
71 min
A selection of talks on Neurology
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