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1. Introduction
2. Talk outline
3. Definition of severe asthma
4. GINA 2006: asthma treatment steps (1)
5. Evaluation of difficult asthma
6. Alternative diagnoses for difficult-to-treat asthma
7. Factors contributing to loss of control in asthma
8. Asthma co-morbidities
9. Definition of refractory asthma
10. Severe asthma research program (SARP)
11. SARP: demographics and treatments
12. SARP: lung function & inflammatory markers
13. GINA 2006: asthma treatment steps (2)
14. Therapeutic approach: step 4
15. Therapeutic approach: step 5
16. Omalizumab on exacerbations in severe asthma
17. Omalizumab in severe asthma: AQLQ
18. Omalizumab for severe persistent allergic asthma
19. Oral steroid-sparing agents
20. Therapeutic approaches: the next 20 years
21. Characteristics of severe asthma: heterogeneity
22. Concept of phenotype
23. SARP/NIH asthma cohort: cluster analysis (1)
24. SARP/NIH asthma cohort: cluster analysis (2)
25. Chronic airflow obstruction
26. Severe asthma protocol
27. Chronic airflow obstruction (1)
28. Chronic airflow obstruction (2)
29. Air-trapping in severe and non-severe asthma
30. Air-trapping in severe asthma: SARP data
31. Inflammatory & remodelling response in airways
32. Submucosal biopsies in severe asthma
33. Inflammatory cells in bronchial biopsies
34. Induced sputum cells in severe asthma
35. Sputum eosinophilic marker asthma analysis
36. Airway wall remodelling in severe asthma
37. HRCT and histology of airway
38. Corticosteroid insensitivity in severe asthma
39. Corticosteroid-dependent asthma
40. Corticosteroid responsiveness
41. Steroid-suppression of cytokine release
42. Heterogeneity of 'causes' of CS insensitivity
43. New treatments for severe asthma? (1)
44. New treatments for severe asthma? (2)
45. Mepolizumab in refractory eosinophilic asthma
46. Effect of mepolizumab on exacerbations
47. Treatment of severe asthma: summary

Topics Covered

• Definition and characterisation
• From difficult-to-treat asthma to severe asthma
• Phenotypes and characteristics
• Current treatment modalities
• Chronic airflow obstruction
• Corticosteroid insensitivity
• Future treatments: specific targets for specific phenotypes

Links

Series:

• Advances in Asthma

Categories:

• Biochemistry
• Cell Biology
• Clinical Medicine
• Diseases, Disorders & Treatments
• Immunology
• Pharmaceutical Sciences

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on December 27, 2012

Financial Disclosures

• Prof. Fan Chung has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.