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• 46 min
  1. Genetic defects and calcium

  • Prof. Tullio Pozzan
• 38 min
  2. Pancreatitis and calcium signaling

  • Prof. Ole Petersen
• 28 min
  3. Ca2+ alterations in familial Alzheimer's disease (FAD)

  • Dr. Paola Pizzo
• 48 min
  4. Ca2+ signaling alterations in Alzheimer's disease

  • Dr. Grace Stutzmann
• 30 min
  5. Nociception and alpha2delta3

  • Dr. Greg Neely
• 45 min
  6. Disease hot spots of ryanodine receptors

  • Dr. Filip Van Petegem
• 46 min
  7. Calcium channelopathies

  • Dr. David Friel
• 27 min
  8. Ca2+, the endoplasmic reticulum and cardiac pathology

  • Prof. Marek Michalak
• 47 min
  9. Mechanism-based therapies for heart failure and cardiac arrhythmias

  • Prof. Andrew Marks
• 49 min
  10. Store-operated Ca2+ entry and vascular smooth muscle remodeling

  • Prof. Mohamed Trebak
• 43 min
  11. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease

  • Prof. Laura del Senno
• 21 min
  12. Acidocalcisomes: conserved from bacterial to human cells

  • Prof. Roberto Docampo
• 26 min
  13. Cellular signaling on host-malaria parasite interactions

  • Prof. Dr. Celia Regina da Silva Garcia
• 34 min
  14. Ca(v)1.3 and deafness

  • Dr. Amy Lee
• 38 min
  15. Immunodeficiencies and pathologies associated with mutations in STIM/ORAI

  • Dr. Thierry Capiod
• 31 min
  16. Vascular calcification location, formation and biological activity

  • Dr. Diane Proudfoot
• Archived Lectures *These may not cover the latest advances in the field
• 31 min
  17. Ca2+ channelopathies

  • Dr. David Friel

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Store operated calcium entry (SOCE)
3. Measurement of SOCE activity
4. ICRAC
5. Whole cell ICRAC amplification
6. STIM1 & Orai1
7. STIM1 & Orai1 colocalize
8. STIM1 & Orai1 in mammals
9. Vascular smooth muscle
10. The arterial tunics
11. Muscle proliferation and migration
12. Diseases of smooth muscle dysfunction
13. Balloon angioplasty
14. Restenosis in the rat model
15. Phenotypic switch of the muscle
16. Phenotypic switching and vascular disease
17. STIM1 & Orai1 in synthetic VSMC
18. STIM1 & Orai1 role in mediating SOCE in VSMC
19. STIM1 & Orai1 mediate CRAC currents in VSMC
20. STIM1 & Orai1: VSMC migration & proliferation
21. STIM1 & Orai1 in an animal model
22. STIM1 & Orai1 and restenosis in rats (1)
23. STIM1 & Orai1 and restenosis in rats (2)
24. shRNA against STIM1 & Orai1: in vivo knockdowns
25. In vivo knockdowns (1)
26. In vivo knockdowns (2)
27. In vivo knockdowns (3)
28. NFAT nuclear translocation and activity
29. Platelet derived growth factor
30. Conclusions
31. STIM1 & Orai1 as drug targets
32. Acknowledgments

Topics Covered

• Store-operated Ca2+ entry (SOCE)
• Measuring SOCE
• The whole-cell current mediated by SOCE, ICRAC
• The molecular players and mechanisms of activation of SOCE
• Vascular Smooth muscle cell (VSMC) remodeling
• VSMC organization and function
• VSMC contribution to vascular disease
• VSMC remodeling in restenosis
• VSMC remodeling and expression of ion channel/transporters
• SOCE and VSMC remodeling
• Role of STIM1 and Orai1 in VSMC SOCE and ICRAC
• STIM1 and Orai1 upregulation in VSMC from injured rat carotid vessels
• Role of STIM1 and Orai1 in driving VSMC remodeling in vivo
• STIM1- and Orai1-mediated SOCE and NFAT activity in VSMC
• STIM1 and Orai1 and SOCE in response to the potent proliferative and migratory agonist, PDGF

Links

Series:

• Calcium Signaling II

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 31, 2012

Financial Disclosures

• Prof. Mohamed Trebak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.