Registration for a live webinar on 'Innate immunity, inflammation and cancer' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- View the Talks
-
1. Genetic defects and calcium
- Prof. Tullio Pozzan
-
2. Pancreatitis and calcium signaling
- Prof. Ole Petersen
-
3. Ca2+ alterations in familial Alzheimer's disease (FAD)
- Dr. Paola Pizzo
-
4. Ca2+ signaling alterations in Alzheimer's disease
- Dr. Grace Stutzmann
-
5. Nociception and alpha2delta3
- Dr. Greg Neely
-
6. Disease hot spots of ryanodine receptors
- Dr. Filip Van Petegem
-
7. Calcium channelopathies
- Dr. David Friel
-
8. Ca2+, the endoplasmic reticulum and cardiac pathology
- Prof. Marek Michalak
-
9. Mechanism-based therapies for heart failure and cardiac arrhythmias
- Prof. Andrew Marks
-
10. Store-operated Ca2+ entry and vascular smooth muscle remodeling
- Prof. Mohamed Trebak
-
11. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease
- Prof. Laura del Senno
-
12. Acidocalcisomes: conserved from bacterial to human cells
- Prof. Roberto Docampo
-
13. Cellular signaling on host-malaria parasite interactions
- Prof. Dr. Celia Regina da Silva Garcia
-
14. Ca(v)1.3 and deafness
- Dr. Amy Lee
-
16. Vascular calcification location, formation and biological activity
- Dr. Diane Proudfoot
- Archived Lectures *These may not cover the latest advances in the field
-
17. Ca2+ channelopathies
- Dr. David Friel
Printable Handouts
Navigable Slide Index
- Introduction
- The endoplasmic reticulum (1)
- The endoplasmic reticulum (2)
- Endoplasmic reticulum luminal environment
- The sarcoplasmic reticulum
- Calcium and cardiac pathology
- Calreticulin deficient embryos
- Incomplete development of septum
- Agonist calcium release in mutant cells
- Calcium dependent transcription factors
- Impact of calreticulin on Ca2+ homeostasis
- Calreticulin deficiency loss of function
- Embryonic stem cells studies
- ES cell derived embryoid body
- Isolated ES cell-derived cardiomyocytes
- Differentiation without calreticulin
- Incorrectly formed sarcomeric structures
- Important domains
- Calcium and cardiogenesis
- Calreticulin is critical for cardiogenesis
- Impact of increased level of calreticulin
- Reduced SOCE in calreticulin expressing cells
- Calreticulin gain of function
- Gain of function and disease
- Embryonic stem cells and gain of function
- Contractile function
- MHC promoter activity
- Pacemaker cells
- The cardiac conductive system
- Tamoxifen inducible calreticulin mice
- Dilated cardiomyopathy and fibrosis
- Dilated cardiomyopathy and heart failure
- Cardiac hypertrophy genes
- Membrane associated proteins
- Summary of talk
- Take home message
Topics Covered
- Molecular studies on the endoplasmic reticulum (ER) function and ER associated chaperones including calreticulin
- ER-associated functions are crucial in cardiac physiology and pathology -ER stress responses
- ER calcium buffering proteins impact many cardiac functions including cardiogenesis, ischemia and reperfusion, cardiomyopathies and heart failure
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Michalak, M. (2012, October 31). Ca2+, the endoplasmic reticulum and cardiac pathology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/2409/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Marek Michalak has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.