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1. Genetic defects and calcium
- Prof. Tullio Pozzan
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2. Pancreatitis and calcium signaling
- Prof. Ole Petersen
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3. Ca2+ alterations in familial Alzheimer's disease (FAD)
- Dr. Paola Pizzo
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4. Ca2+ signaling alterations in Alzheimer's disease
- Dr. Grace Stutzmann
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5. Nociception and alpha2delta3
- Dr. Greg Neely
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6. Disease hot spots of ryanodine receptors
- Dr. Filip Van Petegem
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7. Calcium channelopathies
- Dr. David Friel
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8. Ca2+, the endoplasmic reticulum and cardiac pathology
- Prof. Marek Michalak
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9. Mechanism-based therapies for heart failure and cardiac arrhythmias
- Prof. Andrew Marks
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10. Store-operated Ca2+ entry and vascular smooth muscle remodeling
- Prof. Mohamed Trebak
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11. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease
- Prof. Laura del Senno
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12. Acidocalcisomes: conserved from bacterial to human cells
- Prof. Roberto Docampo
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13. Cellular signaling on host-malaria parasite interactions
- Prof. Dr. Celia Regina da Silva Garcia
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14. Ca(v)1.3 and deafness
- Dr. Amy Lee
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16. Vascular calcification location, formation and biological activity
- Dr. Diane Proudfoot
- Archived Lectures *These may not cover the latest advances in the field
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17. Ca2+ channelopathies
- Dr. David Friel
Printable Handouts
Navigable Slide Index
- Introduction
- Finding key conserved "disease" genes
- Drosophila: good model for human "disease" genes
- VDRC genome wide RNAi in Drosophila
- Using the RNAi library
- Pain behavior in fruit fly
- Finding conserved regulators of nociception
- High temperature is noxious to Drosophila
- Assay for nociception in adult flies
- Drosophila rapidly avoid high temperature
- Painless mutant flies & noxious temperatures
- Nociception screening system in adult fly
- Genome wide nociception screen in adult fly
- Screening data (pathway enrichment)
- Human GWAS for chronic pain after back surgery
- Human GWAS vs. calcium signaling
- Straightjacket (stj) is a novel fly "pain" gene
- stj is found in brain & peripheral sensory neurons
- alpha-2-delta-3 (stj): Drosophila larvae "pain" gene
- alpha-2-delta-3 mutant larvae
- Generation of alpha-2-delta-3 KO mice
- KO mice show delayed nociception responses
- alpha-2-delta-3 KO mice basic phenotype
- The pain circuit
- Problem - no difference in a tail flick assay
- alpha-2-delta-3 may act in the brain
- KO mice: possible altered pain processing in brain
- fMRI setup
- alpha-2-delta-3: thalamus to SSC transmission
- Problem - there is overall normal total brain activity
- Loss of alpha-2-delta-3
- alpha-2-delta-3 (stj): an acute & chronic pain gene
- Conclusions
- Acknowledgements
Topics Covered
- Finding key conserved pain genes in drosophila as a model for human genes
- Finding conserved regulators of nociception
- Assay for nociception in adult flies
- Painless mutant flies & noxious temperatures
- Genome wide nociception screen in adult fly
- Human GWAS for chronic pain gene
- Alpha-2-delta-3 (Straightjacket = stj) as a novel acute & chronic pain gene and the effect on its manipulation in mice and flies
Links
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Talk Citation
Neely, G. (2012, October 31). Nociception and alpha2delta3 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/2406/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Greg Neely has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.