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1. Genetic defects and calcium
- Prof. Tullio Pozzan
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2. Pancreatitis and calcium signaling
- Prof. Ole Petersen
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3. Ca2+ alterations in familial Alzheimer's disease (FAD)
- Dr. Paola Pizzo
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4. Ca2+ signaling alterations in Alzheimer's disease
- Dr. Grace Stutzmann
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5. Nociception and alpha2delta3
- Dr. Greg Neely
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6. Disease hot spots of ryanodine receptors
- Dr. Filip Van Petegem
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7. Calcium channelopathies
- Dr. David Friel
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8. Ca2+, the endoplasmic reticulum and cardiac pathology
- Prof. Marek Michalak
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9. Mechanism-based therapies for heart failure and cardiac arrhythmias
- Prof. Andrew Marks
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10. Store-operated Ca2+ entry and vascular smooth muscle remodeling
- Prof. Mohamed Trebak
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11. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease
- Prof. Laura del Senno
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12. Acidocalcisomes: conserved from bacterial to human cells
- Prof. Roberto Docampo
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13. Cellular signaling on host-malaria parasite interactions
- Prof. Dr. Celia Regina da Silva Garcia
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14. Ca(v)1.3 and deafness
- Dr. Amy Lee
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16. Vascular calcification location, formation and biological activity
- Dr. Diane Proudfoot
- Archived Lectures *These may not cover the latest advances in the field
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17. Ca2+ channelopathies
- Dr. David Friel
Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Neurons are unique cells
- Calcium signaling pathways in neurons
- Calcium signaling in neurons
- The ER is distributed throughout the neuron
- Calcium induced calcium release
- Visualizing the CICR
- Calcium signaling pathways in neurons
- Excess calcium leads to cellular pathology
- How ER calcium signaling is linked to AD
- Alzheimer's disease
- Presenilin mutations
- Support for the calcium hypothesis of AD
- Transgenic AD mice
- PS1KI vs. non-tg ER calcium responses
- NonTg vs. AD ER calcium responses
- Three possible mechanisms
- The RyR is upregulated in AD mice at early ages
- RyR-evoked calcium release
- Dysregulated ER calcium affects neurophysiology
- Effects of altered ER calcium dysregulation
- AD neuron - higher postsynaptic calcium response
- Aberrant CICR in AD mice generated by NMDAR
- Sensitized CICR via the RyR
- Effects of dysregulated ER calcium signaling
- Baseline and presynaptic plasticity mechanisms
- Blocking the RyR affects LTP expression
- Blocking the RyR affects LTD expression
- How enhanced calcium may 'enable' AD? (1)
- Complex dynamic interactions - a summary
- Beta amyloid peptides and plaque deposition
- Hyperphosphorylated tau and calcium
- ApoE4 alleles
- Apoptosis and toxicity
- How enhanced calcium may 'enable' AD? (2)
Topics Covered
- Neuronal Ca2+ signaling pathways and associated functions/dysfunctions
- Alzheimer's disease, features and mechanisms
- Alzheimer's disease and calcium signaling deficits, sources, specific effects on synaptic transmission, early and late contributions to pathology
- How dysregulated calcium can feed into AD pathology
Links
Series:
Categories:
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Talk Citation
Stutzmann, G. (2012, October 31). Ca2+ signaling alterations in Alzheimer's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/2405/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Grace Stutzmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.