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1. Mononuclear phagocytes - origins, fates and functions
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2. Transcription factors in macrophage differentiation
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3. Fetal macrophages
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4. The alveolar macrophage
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5. Airway macrophages in health and disease
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6. Intestinal macrophages - heterogeneity, origins and functions
- Prof. Allan Mowat
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7. Osteoclasts: what do they do and how do they do it?
- Prof. Steven L. Teitelbaum
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8. The biology of Fc receptors and complement receptors
- Prof. Steven Greenberg
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10. Tumour-associated macrophages
- Prof. Michele De Palma
- Dr. Mario Squadrito
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11. The recognition of pathogens by C-type lectins
- Prof. Gordon D. Brown
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12. Macrophage phagocytosis
- Prof. Joel Swanson
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13. Macrophage CD36 and atherosclerosis
- Dr. Maria Febbraio
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14. Toll-Like receptor signaling and the innate immune response
- Dr. Kate Fitzgerald
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15. Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria
- Prof. Ricardo Gazzinelli
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17. Triggering receptors expressed on myeloid cells (TREM)
- Dr. Daniel W. McVicar
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18. Influence of eicosanoid lipid mediators on macrophage innate immune functions
- Prof. Marc Peters-Golden
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19. Macrophage paired receptor interactions
- Prof. Neil Barclay
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20. Macrophage heterogeneity in atherosclerosis regression
- Prof. Edward Fisher
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21. Gaucher disease: from lysosomal storage to immunopathology
- Prof. Johannes M.F.G. Aerts
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22. Macrophage in asthma
- Prof. Douglas Robinson
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23. The macrophage mannose receptor
- Dr. Luisa Martinez-Pomares
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24. Myeloid-derived suppressor cells in cancer
- Prof. Dmitry Gabrilovich
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25. EGF-TM7 receptors
- Dr. Jörg Hamann
- Dr. Hsi-Hsien Lin
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26. Macrophages in helminth infection
- Prof. Judith Allen
- Archived Lectures *These may not cover the latest advances in the field
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27. Immunosuppressive mechanisms in myeloid cells
- Prof. Dmitry Gabrilovich
Printable Handouts
Navigable Slide Index
- Introduction
- Innate immune receptors for malaria parasites
- Malaria distribution in the world
- Plasmodium life cycle
- The malaria disease
- Cytokines & septic shock-like syndrome in malaria
- Anemia and RBC destruction
- Adhesion of iRBCs to capillary
- The three main events in pathogenesis of malaria
- Malaria toxin hypothesis
- The GPI anchor of plasmodium: "malaria toxin"
- Malaria PAMPs
- Hemozoin levels in circulating phagocytes
- Hemozoin recognition by innate immune receptors
- Innate immune response in Drosophila & humans
- Innate immune recognition system
- Phagocytized hemozoin and TLR9 in the lysosome
- CpG & AT-rich ODN: different immune pathways
- The inflammatory component of hemozoin is DNA
- Malaria clinical research site in Brazil
- Pro-inflammatory priming in malaria
- Hyper-responsive malarial PBMCs to TLR agonists
- Relation between malaria and bacteremia
- TLR hyper-responsiveness in malaria: in vivo
- Excessive pro-inflammatory response in malaria
- Fever, inflammasome, caspase-1 and IL-1beta
- Inflammatory cytokines during acute malaria
- Inflammasome related genes in acute malaria
- Jurg Tschopp (studying the inflammasome)
- The NALP3 inflammasome
- ASC oligomerization
- ASC aggregation & caspase-1 during infection
- Caspase-1 & inflammatory cell death in infection
- Inflammasome components during infection
- Caspase-1 activation: dependent on Nalp 3 & 12
- IL-1 is a critical cytokine mediating lethality
- Activation of innate immune receptors
- Conclusions I
- Targeting nucleic acid sensing-TLRs & malaria
- AT7/9-2: inhibitor of nucleic acid sensing-TLRs
- AT7/9 accumulates in the endosome
- Assessment of DNA binding of TLR9 antagonist
- Protective effect of the TLR9 antagonist in malaria
- Conclusions II
- Plasmodium parasite phagocytic cell activation
- The innate immunity - a double edged sword
- Acknowledgements
Topics Covered
- Malaria and Plasmodium parasites
- Innate immune receptors
- Plasmodium recognition by host innate immune receptors, and in particular by Toll-like Receptors (TLRs)
- Excessive activation of TLRs and pathogenesis of malaria inflammasome
- Caspase-1 induced inflammation and fever in malaria
- Use of a TLR antagonist to treat experimental cerebral malaria
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Talk Citation
Gazzinelli, R. (2013, April 4). Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/EVVK2959.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ricardo Gazzinelli has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Innate immune receptors as mediators of systemic inflammation and pathogenesis of malaria
Published on April 4, 2013
43 min
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