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42 min
1. Historic introduction to innate immunity- Prof. Heiko Herwald
- Prof. Arne Egesten
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52 min
2. Evolution of innate immunity- Prof. Jim Kaufman
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25 min
3. The phagocytic synapse in distinguishing particulate and soluble stimuli- Prof. David Underhill
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23 min
4. How bacterial pathogens avoid phagocyte killing- Dr. Thomas Areschoug
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43 min
5. Origin of myeloid cells- Prof. Frederick A. Geissmann
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67 min
6. Dendritic cells- Prof. Muriel Moser
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38 min
7. Eosinophil biology and disorders associated with eosinophilia- Dr. Thomas B. Nutman
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60 min
8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity- Prof. Steven A. Porcelli
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50 min
9. Innate-like B cells- Prof. John F. Kearney
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58 min
10. Cytoplasmic innate immune sensors- Prof. Seth Masters
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76 min
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28 min
12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome- Prof. Robert Wilkinson
- Prof. Graeme Meintjes
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37 min
13. Antimicrobial peptides in the innate immune system of the lung- Prof. Dr. Pieter S. Hiemstra
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49 min
14. Chemokines and their receptors: their biology and therapeutic relevance- Dr. Amanda Proudfoot
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45 min
15. Heat shock proteins and their role in the immune regulation of inflammation- Prof. Willem Van Eden
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42 min
16. Tissue damage control confers host tolerance to infection- Dr. Miguel P. Soares
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22 min
17. Autophagy as a barrier to infection- Prof. Michele Swanson
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42 min
18. Innate immunity in the intestine in health and disease- Prof. Kevin Maloy
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51 min
19. Dendritic cells and the eye: their role in the ocular immune response- Prof. John V. Forrester
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26 min
20. Mononuclear phagocytes and HIV infection- Dr. Guido Poli
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41 min
21. Th17 cells and innate immunity- Prof. Mihai Netea
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37 min
22. Epigenetic regulation of innate immunity- Dr. Osamu Takeuchi
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66 min
23. Intracellular DNA sensing pathways- Prof. Veit Hornung
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52 min
24. Physiology of innate immunity- Prof. Keith W. Kelley
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49 min
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32 min
26. Regulation of type 2 immunity by basophils- Prof. David Voehringer
- Archived Lectures *These may not cover the latest advances in the field
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53 min
27. TLRs, NLRs, DAMPs and PAMPs- Prof. Luke O'Neill
Printable Handouts
Navigable Slide Index
- Introduction
- Pathogens\Commensals at the mucosal level
- Urinary tract infections (UTI)
- UTI frequency
- Uropathogenic Escherichia coli virulence
- Asymptomatic carrier strains
- Uropathogenic E. coli vs. ABU strains
- Human UTI- resistance v. susceptibility
- Host resistance in the murine UTI model
- Innate immune control of host resistance
- Innate immune response and effector function
- How pathogenic bacteria activate a host response
- Uropathogenic E. coli, attachment and disease
- P fimbriae and recognition receptors
- Pathogen specific innate immune signaling (1)
- TLR4-ceramide interactions defined by FRET
- Proteomic and transcriptomic analysis
- Nuclear IRF-3 translocation
- Importance of identifying signaling pathways
- Pathogen specific innate immune signaling (2)
- IRF3 knock out
- IRF3 -/- phenotype
- IL8 receptor knock out
- IL-8 and IL-8R; neutrophils are crucial effector cells
- Neutrophil exodus across the mucosa
- mIL-8Rh-/-mice
- IL-8 receptor phenotype
- IL-8R KO phenotype
- Neutrophil entrapment in IL-8R KO mice
- Neutrophils accumulate in the kidneys
- mIL-8R KO mice develop renal scarring
- Acute and chronic pyelonephritis
- Conclusions, IRF3 and IL-8
- TLR4 -/- mice
- Asymptomatic bacteriuria in C3H/HeJ & Tlr4 KO's
- Conclusion: Loss of TLR4 protects
- Genetic variance affects UTI progression
- Genetic susceptibility to UTI
- Human UTI susceptibility
- Researching disease-associated polymorphisms
- IRF3 promoter polymorphisms in UTI patients
- The SNPs reduce IRF3 promoter activity
- Clinical studies to identify CXCR1 polymorphisms
- CXCR1 sequencing
- SNP1 affects AML1 dependent transcription
- SNP frequency in APN-prone patients and controls
- Variant frequency-APN-prone children vs. controls
- TLR4 - prediction from the mouse model
- Clinical studies to identify TLR4 polymorphisms
- Children with ABU have low TLR4 expression
- Many have looked for mutations in structural genes
- New TLR4 promoter polymorphisms
- SNP genotype frequency in children with UTI
- TLR4 promoter genotype in asymptomatic carriers
- Low response to infection in reporter assays
- Summary-TLR4, CXCR1, IRF3 role in UTI response
- Susceptibility to UTI can be inherited
- Commensalism vs. Virulence
- Future consequences for diagnosis and therapy
- Contributors & Thanks
Topics Covered
- Pathogens\Commensals at the mucosal level
- How pathogenic bacteria activate a host response
- Pathogen specific innate immune signaling
- Urinary tract infections (UTI)
- Uropathogenic E. coli vs. ABU strains
- TLR4, CXCR1, IRF3, IL8R role in UTI response
- Importance of identifying signaling pathways & crucial effector cells
- Acute/Chronic pyelonephritis & asymptomatic bacteriuria
- Genetics & UTI
- Researching disease-associated polymorphisms
- SNPs and their effect in APN & UTI
- Mutations in structural genes
- Response to infection in reporter assays
- Commensalism vs. Virulence
Links
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Talk Citation
Svanborg, C. (2012, June 11). Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/2287/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Catharina Svanborg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage
Published on June 11, 2012
49 min
A selection of talks on Immunology
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