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• 42 min
  1. Historic introduction to innate immunity

  • Prof. Heiko Herwald
  • Prof. Arne Egesten
• 52 min
  2. Evolution of innate immunity

  • Prof. Jim Kaufman
• 25 min
  3. The phagocytic synapse in distinguishing particulate and soluble stimuli

  • Prof. David Underhill
• 23 min
  4. How bacterial pathogens avoid phagocyte killing

  • Dr. Thomas Areschoug
• 43 min
  5. Origin of myeloid cells

  • Prof. Frederick A. Geissmann
• 67 min
  6. Dendritic cells

  • Prof. Muriel Moser
• 38 min
  7. Eosinophil biology and disorders associated with eosinophilia

  • Dr. Thomas B. Nutman
• 60 min
  8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity

  • Prof. Steven A. Porcelli
• 50 min
  9. Innate-like B cells

  • Prof. John F. Kearney
• 58 min
  10. Cytoplasmic innate immune sensors

  • Prof. Seth Masters
• 76 min
  11. An introduction to the interleukin-1 family of cytokines

  • Dr. John Sims
• 28 min
  12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome

  • Prof. Robert Wilkinson
  • Prof. Graeme Meintjes
• 37 min
  13. Antimicrobial peptides in the innate immune system of the lung

  • Prof. Dr. Pieter S. Hiemstra
• 49 min
  14. Chemokines and their receptors: their biology and therapeutic relevance

  • Dr. Amanda Proudfoot
• 45 min
  15. Heat shock proteins and their role in the immune regulation of inflammation

  • Prof. Willem Van Eden
• 42 min
  16. Tissue damage control confers host tolerance to infection

  • Dr. Miguel P. Soares
• 22 min
  17. Autophagy as a barrier to infection

  • Prof. Michele Swanson
• 42 min
  18. Innate immunity in the intestine in health and disease

  • Dr. Kevin Maloy
• 51 min
  19. Dendritic cells and the eye: their role in the ocular immune response

  • Prof. John V. Forrester
• 26 min
  20. Mononuclear phagocytes and HIV infection

  • Dr. Guido Poli
• 41 min
  21. Th17 cells and innate immunity

  • Prof. Mihai Netea
• 37 min
  22. Epigenetic regulation of innate immunity

  • Dr. Osamu Takeuchi
• 66 min
  23. Intracellular DNA sensing pathways

  • Prof. Veit Hornung
• 52 min
  24. Physiology of innate immunity

  • Prof. Keith W. Kelley
• 49 min
  25. Innate immunity in the genitourinary tract: genetics of susceptibility to disease or asymptomatic carriage

  • Prof. Catharina Svanborg
• 32 min
  26. Regulation of type 2 immunity by basophils

  • Prof. David Voehringer
• Archived Lectures *These may not cover the latest advances in the field
• 53 min
  27. TLRs, NLRs, DAMPs and PAMPs

  • Prof. Luke O'Neill

Printable Handouts

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Navigable Slide Index

1. Introduction
2. The HIV pandemic - 2010
3. HIV structure
4. HIV targets cells express CD4 & CCR5 or CXCR4
5. The HIV life cycle
6. Macrophages as "Trojan horses" of HIV virions
7. HIV infection of T cells and macrophages
8. Mononuclear phagocytes differentiation & HIV
9. HIV infects bone marrow MP precursors in vitro
10. HIV Infects bone marrow MP precursors in vivo
11. HIV affects the function of circulating monocytes
12. HIV infects circulating monocytes
13. HIV & tissue macrophages
14. HIV & the brain
15. Intestinal macrophages don't express HIV Co-R
16. Intestinal macrophages are not infectible by HIV
17. Intestinal vs. blood macrophages
18. HIV replication in myelo-monocytic cell lines
19. Promonocytic U937 & U1 cell lines (1)
20. Promonocytic U937 & U1 cell lines (2)
21. Inhibition of HIV-1 replication in minus U937 cells
22. Differential expression of HMGB1-R in U937 cells
23. Only minus U937 cell clones express TRIM22
24. Promonocytic U937 & U1 cell lines (3)
25. Differential effect of IFN-alpha and IFN-gamma (1)
26. Differential effect of IFN-alpha and IFN-gamma (2)
27. Does polarization influence susceptibility to HIV?
28. Human macrophages can be polarized
29. Polarization of monocyte-derived macrophages
30. M1 and M2a polarization inhibits HIV-1 replication
31. Functional differences between M1 and M2 MDM
32. Differential inhibitory effects of M1 vs. M2 on HIV-1
33. Conclusions
34. Acknowledgments

Topics Covered

• The HIV pandemic
• HIV structure
• HIV target cells and their viral receptors
• HIV life cycle
• Macrophages as "Trojan horses" of HIV
• Comparison of HIV infection of T cells and macrophages
• Macrophage differentiation
• HIV infection of bone marrow precursors in vitro and in vivo
• Functional defects of monocytes
• HIV and tissue macrophages
• HIV and the brain
• HIV and intestinal macrophages
• HIV replication in monocytic cell lines
• U937 and U1 cell lines
• HMGB1 and HIV infection of U937 cells
• U937 cell clones and TRIM22
• IFNs and HIV infection of macrophages
• Human macrophage polarization and HIV infection
• Macrophage polarization and inhibition of HIV replication
• Differences between M1 and M2 macrophages in inhibiting HIV replication

Links

Series:

• Cells of the Innate Immune System

Categories:

• Biochemistry
• Cell Biology
• Diseases, Disorders & Treatments
• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on April 3, 2012

Financial Disclosures

• Dr. Guido Poli has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.