• Overview of Chaperone Networks
• 41 min
  1. Mapping the molecular chaperone interaction network in yeast

  • Prof. Walid A. Houry
• 30 min
  2. The interaction network of the GroEL chaperonin

  • Prof. Dr. F. Ulrich Hartl
• 61 min
  3. Human heat shock protein families

  • Prof. Herman Kampinga
• 42 min
  4. Extracellular proteostasis: an emerging field

  • Prof. Mark Wilson
• 36 min
  5. Protein homeostasis and the chaperone interaction network in Arabidopsis thaliana

  • Prof. Rongmin Zhao
• Proteasome Networks
• 64 min
  6. Biogenesis of the eukaryotic proteasome

  • Prof. Mark Hochstrasser
• Understanding Intrinsically Disordered Proteins in Protein Homeostasis
• 36 min
  7. Intrinsically unstructured proteins: regulation and disease

  • Dr. M. Madan Babu
• 43 min
  8. The roles of intrinsic disorder in protein interaction networks

  • Prof. Vladimir N. Uversky
• Gene Regulatory Networks and their Role in Protein Homeostasis
• 38 min
  9. Network motifs: basic building blocks of biological networks

  • Prof. Uri Alon
• 41 min
  10. Structure, evolution and dynamics of gene regulatory networks

  • Dr. M. Madan Babu
• 33 min
  11. Computational methods in analysis of gene regulation and protein interactions

  • Prof. Ron Shamir
• 51 min
  12. Protein-protein interaction networks

  • Prof. Peter Csermely
• Protein Homeostasis in the Endoplasmic Reticulum
• 56 min
  13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum

  • Prof. David B. Williams
• 30 min
  14. The unfolded protein response

  • Prof. Kazutoshi Mori
• 38 min
  15. Role of ER stress in cystic fibrosis airway inflammation

  • Dr. Carla Maria Pedrosa Ribeiro
• 57 min
  16. The recognition of misfolded glycoproteins in the endoplasmic reticulum

  • Dr. David Y. Thomas
• 49 min
  17. Chaperone systems of the endoplasmic reticulum

  • Prof. Linda M. Hendershot
• 74 min
  18. The ERAD network

  • Prof. Daniel Hebert
• Protein Homeostasis in the Mitochondria
• 22 min
  19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases

  • Dr. David A. Dougan
• 46 min
  20. Protein homeostasis in mitochondria: chaperones and proteases of the mitochondrial matrix

  • Prof. Wolfgang Voos
• 26 min
  21. Mitochondrial chaperonin Hsp60: locations, functions and pathology

  • Prof. Francesco Cappello
  • Prof. Alberto J. L. Macario
• Protein Homeostasis in the Nucleus
• 23 min
  22. Nuclear protein quality control degradation

  • Dr. Richard G. Gardner
• Protein Homeostasis in Aging Disease
• 27 min
  23. Protein homeostasis during ageing: C. elegans as a model organism

  • Prof. Nektarios Tavernarakis
• Protein Homeostasis in Neurodegeneration
• 41 min
  24. Endoplasmic reticulum stress in neurodegenerative diseases

  • Prof. Claudio Soto
• 48 min
  25. Roles for Hsp40 molecular chaperones in protein misfolding disease

  • Prof. Douglas M. Cyr
• 38 min
  26. Protein folding in vivo

  • Prof. James Bardwell
• 39 min
  27. Protein degradation and defense against neurodegenerative disease 1

  • Prof. Alfred Goldberg
• 42 min
  28. Protein degradation and defense against neurodegenerative disease 2

  • Prof. Alfred Goldberg

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Outcomes of misfolded protein aggregation
3. The study of neurodegenerative diseases
4. Regulation of Hsp70 function by Hsp40
5. Domain structure of Hsp40 family members
6. Functional specificity of Type I and Type II HSP40
7. Hsp70 and Hsp40s act via opposing mechanisms
8. Hsp40s differentially modulate fibril formation
9. RNQ+ as a model system for amyloid assembly
10. Rnq1 forms self-perpetuating aggregates
11. Hsp40 types - opposing roles on RNQ+ assembly
12. Sis1 and Ydj1 recognize different regions of Rnq1
13. Hsp40 types bind different regions of Rnq1 prions
14. Rnq1 elevation kills yeast containing RNQ+ prions
15. Overexpression of Sis1 suppresses Rnq1 toxicity
16. A possible mechanism for Rnq1 toxicity?
17. Sis1 decreases unassembled Rnq1 pool
18. Sis1 promotes RNQ prion accumulation
19. RNQ prion accumulation may help reduce toxicity
20. How type I Hsp40s suppress amyloid formation
21. Rnq1 prion domain overexpression in yeast
22. Ydj1 required for tolerance of PrD overexpression
23. Ydj1 overexpression inhibits PrD aggregation
24. PrD accumulation in the absence of Ydj1
25. A model for PRD prion formation
26. Hsp40s suppress proteotoxicity in different ways
27. Acknowledgements

Topics Covered

• Protein aggregation in conformational disease
• The Hsp40 system
• The Hsp70 system
• Small oligomers, prion, yeast, Huntington's disease and protein triage
• Mechanisms for proteotoxicity
• Mechanisms for amyloid disease

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on February 20, 2012

Financial Disclosures

• Prof. Douglas M. Cyr has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.