Registration for a live webinar on 'Innate immunity, inflammation and cancer' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Principles in Bacterial Pathogenesis
-
1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
-
2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
-
5. Bordetella pertussis
- Prof. Alison Weiss
-
6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
-
7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
-
8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
-
9. Human pathogenic Yersinia species
- Prof. James Bliska
-
11. Dental pathogens
- Prof. Ann Progulske-Fox
-
12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
-
13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
-
15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
-
16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
-
17. Microbial recognition and the immune response
- Dr. Dana Philpott
-
18. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
-
19. The human indigenous microbiota
- Prof. David Relman
-
21. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
-
22. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
-
23. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
-
24. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
-
25. Vaccines in the modern world
- Prof. Gordon Dougan
-
26. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Acute lung injury
- ALI and ARDS: consensus definition
- ALI/ARDS and inflammation
- Inflammation in acute lung injury
- ALI: an inflammatory lung disease
- The paradox
- Selected basics of neutrophil biology
- Hematopoiesis
- Mature neutrophils
- The neutrophil: king of phagocytosis
- Phagocytosis (1)
- Phagocytosis (2)
- Neutrophil granules
- Phagocyte NADPH oxidase (NOX2)
- Neutrophil adhesion and emigration
- Back to the lung
- PMN sequestration mechanisms in ALI
- PMN sequestration in pulmonary capillaries
- PMN transiting a model capillary in vitro
- Leukocyte sequestration in ARDS
- Epithelial (epi.) function in lung injury
- Mechanisms and consequences of PMN migration
- Inter-epithelial cell junctions
- Inter-epithelial (i-epi.) junctional molecules
- In vitro model of PMN transmigration
- PMN transepithelial migration
- PMN migration creates areas of microinjury (1)
- PMN migration creates areas of microinjury (2)
- I-epi. junction disruption and neutrophil infiltration
- Elastase and trans-epithelial resistance decrease
- E-cadherin cleavage by PMN elastase
- Inter-epithelial junctional molecules cadherins
- Epi. injury mechanisms induces by PMN migration
- Epithelial apoptosis following PMN transmigration
- Elastase induces epithelial cell apoptosis (1)
- Elastase induces epithelial cell apoptosis (2)
- Mechanisms of elastase-induced apoptosis
- Pathways of apoptosis
- Elastase increases mitochondrial permeability
- Elastase induces cleavage of caspases 9 and 3
- Protease activated receptors
- PAR-1 siRNA blocks elastase-induced apoptosis
- Epithelial repair after ALI
- PMN transmigration: epithelial injury and repair
- Alterations in epithelial gene expression
- Ingenuity pathway analysis (1)
- Ingenuity pathway analysis (2)
- Wnt/beta-catenin pathway
- PMN transmigration induces beta-catenin signaling
- PMN migration induces beta-catenin translocation
- PMN transmigration induces TOPFlash activity
- Beta-catenin genes upregulated by PMN migration
- PMN migration and beta-catenin activation in vivo
- Beta-catenin dependent transcription and PMNs
- PMN migration induces cyclin D1 expression
- Functional role of beta-catenin in injury and repair
- ShRNA knockdown of beta-catenin
- Beta-catenin in epithelial injury and repair
- Conclusions
- The concepts discussed
- Therapeutic implications
- Acknowledgements
Topics Covered
- Clinical problem of acute lung injury and ARDS
- physiological role of neutrophils in host defense and innate immunity
- pathological role of neutrophils in inflammatory tissue injury in general and in acute lung injury
- mechanisms of damage to the lung epithelium by neutrophils
- paradoxical role of neutrophils in initiating repair processes
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Downey, G. (2011, July 27). Role of neutrophils in acute lung injury and repair [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 29, 2024, from https://hstalks.com/bs/2050/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Gregory Downey has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.