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1. Introduction
2. General pathophysiology of glia
3. Reactive astrogliosis - definition
4. Anisomorphic and isomorphic astrogliosis
5. GFAP upregulation-a hallmark of astrogliosis
6. Initiation and regulation of reactive astrogliosis
7. Astroglial dichotomy - neuroprotective/neurotoxic
8. Alexander's disease (1)
9. Alexander's disease (2)
10. Astrocytes in ischemia and stroke
11. Spatial and temporal progression of stroke (1)
12. Spatial and temporal progression of stroke (2)
13. Astroglia protect the brain against ischaemia
14. Astrocytes may exacerbate brain damage
15. Brain oedema
16. Brain oedema - consequences
17. Hepatic encephalopathy - primary astrocytopathy
18. Possible neuroglial roots of neurodegeneration
19. Neurodegenerative diseases - specific to humans
20. AD - characteristic neurodegeneration
21. AD - glial cells form the neuritic plaque
22. Absence of astroglial loss in AD model animals
23. AD - astroglial atrophy and astrogliosis (1)
24. AD - astroglial atrophy and astrogliosis (2)
25. Complex changes in microglia during AD
26. Astroglial atrophy in neurodegenerative diseases
27. Neuroglial hypothesis of neurodegeneration
28. Conclusion

Topics Covered

• Reactive astrogliosis
• Anisomorphic and isomorphic astrogliosis
• Up-regulation of GFAP synthesis
• Initiation and regulation of reactive astrogliosis
• Neuroprotection and neurotoxicity
• Alexander's disease
• Astrocytes in ischaemia and stroke
• Brain oedema
• Possible neuroglial roots of neurodegeneration

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on June 29, 2011
• Archived on March 31, 2022

Financial Disclosures

• Prof. Alexei Verkhratsky has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.