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Printable Handouts
Navigable Slide Index
- Introduction
- Biological basis
- How does resistance develop?
- Codon and amino acid changes
- Mutations
- Virological response to antiretroviral therapy
- Genotypic and phenotypic resistance
- Mutations selected by PIs
- HIV-1 protease bound to an inhibitor
- Clinical implications
- Resistance accumulates
- Mutations in patients with virologic failure
- Viral rebound rarely reaches pre-therapy levels
- AZT mutations, TAMS, NAMS, etc...
- NRTI resistance (1)
- NRTI resistance (2)
- Protease inhibitors
- Major vs. minor PI mutations
- Protease mutations
- Concentration-time profile: PK enhancement
- Overcoming drug resistance
- Pathways to clinical resistance - NNRTI
- Summary
Topics Covered
- HIV replication and biological basis of drug resistance
- Antiviral drugs
- Emergence of drug resistance in practice
- Measurement of drug resistance
Talk Citation
Pillay, D. (2011, January 16). Antiretroviral drug resistance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/VTQT6020.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Deenan Pillay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.