• The Discovery of Protein Phosphorylation
• 45 min
  1. Phosphorylase and the origin of reversible protein phosphorylation

  • Prof. Edmond Fischer
• 21 min
  2. Three decades of protein phosphorylation and cancer: the identification and characterization of the src gene product

  • Prof. Raymond Erikson
• Protein Kinase Cascades
• 32 min
  3. Role of the PI 3-kinase signaling pathway in cell regulation and human disease

  • Prof. Lew Cantley
• The Modulation of Protein Function by Phosphorylation
• 33 min
  4. Two is the key to 14-3-3: dimeric mechanical signaling devices

  • Prof. Carol MacKintosh
• Protein Phosphatases
• 38 min
  5. Structure and mechanisms of protein phosphatases

  • Prof. David Barford
• 45 min
  6. Protein tyrosine phosphatases

  • Prof. Jack Dixon
• 49 min
  7. The regulation of MAP kinase signalling by dual-specificity protein phosphatases

  • Prof. Steve M. Keyse
• 22 min
  8. Protein phosphatase inhibitors: a distillation of cell signaling research and water toxicology

  • Prof. Carol MacKintosh
• The Structures of Protein Kinases
• 45 min
  9. Protein kinase structure, function and regulation

  • Prof. Susan Taylor
• 42 min
  10. The structural basis for the modulation of protein function by protein phosphorylation

  • Prof. Dame Louise N. Johnson
• Biological Systems that are Regulated by Reversible Phosphorylation
• 50 min
  11. Protein phosphorylation and the control of protein synthesis

  • Prof. Christopher Proud
• 62 min
  12. The role of phosphorylation in mediating cellular responses to DNA damage: the ATM-mediated DNA damage response

  • Prof. Yosef Shiloh
• 40 min
  13. Roles of AMPK in energy homeostasis and nutrient sensing

  • Prof. Grahame Hardie
• 56 min
  14. Serine kinases and T lymphocyte biology

  • Prof. Doreen Cantrell
• 30 min
  15. The interplay between protein phosphorylation and ubiquitylation in the NF-κB pathway

  • Prof. Zhijian 'James' Chen
• 58 min
  16. SMAD phosphorylation and the TGF-beta pathway

  • Prof. Joan Massagué
• Protein Kinases and Human Disease
• 58 min
  17. Function and regulation of the PDK1 kinase

  • Prof. Dario Alessi
• 63 min
  18. LKB1 pathway and its role in cancer

  • Prof. Dario Alessi
• 51 min
  19. WNK1 pathway and its role in regulating hypertension

  • Prof. Dario Alessi
• 33 min
  20. The hyperphosphorylation of tau and Alzheimer's disease

  • Prof. Michel Goedert
• Protein Kinases as Targets for the Development of Anti-Cancer Drugs
• 68 min
  21. PI3K/AKT signaling in cancer

  • Prof. Neal Rosen
• 37 min
  22. RAS and RAF signaling in melanoma: biology and therapies

  • Prof. Richard Marais
• 38 min
  23. The mTOR kinase as a target for anti-cancer drugs

  • Prof. David Sabatini
• Archived Lectures *These may not cover the latest advances in the field
• 51 min
  24. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 38 min
  25. AMP-activated protein kinase: regulating cellular and whole body energy balance

  • Prof. Grahame Hardie

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The human kinome
3. TGF-beta - a paradigm for multifunctionality
4. TGF-beta in tissue homeostasis
5. TGF-beta inhibits cell proliferation
6. TGF-beta induces cell cycle arrest
7. Two sets of CDK inhibitors in TGF-beta action
8. Discovering TGF-beta receptors
9. Mechanism of TGF-beta receptor activation
10. TGF-beta receptor activation switch
11. TGF-beta signaling pathway (1)
12. TGF-beta signaling pathway (2)
13. Smad protein structure and functions
14. Identifying a Smad DNA-binding cofactor
15. Smad DNA-binding cofactors
16. Context-dependent Smad transcriptional action
17. A TGF-beta transcriptional program
18. TGF-beta signaling: cytostatic gene responses
19. Smad pathway cofactors and regulators
20. Smad linker phosphorylation
21. HECT ubiquitin ligases recognize linker-pSmads
22. Agonist-induced linker phosphorylation
23. Linker phosphorylation in mouse embryo
24. CDK8/9 mediate linker phosphorylation
25. Smurf1, Nedd4L bind to CDK8/9
26. Smurf1 and Nedd4L limit length of Smad activation
27. Agonist-induced linker phosphorylation activity
28. CDK8/9 is driving the Smad cycle
29. Transcriptional CDKs
30. Inherited human disorders in TGF-beta and BMP
31. Loeys-Dietz syndrome
32. TGF-beta and cancer
33. Somatic mutations impact TGF-beta-Smad
34. TGF-beta in cancer
35. Cytostatic gene responses lost in cancer
36. TGF-beta-Smad pathway
37. Summary

Topics Covered

• The TGFb family as a paradigm of multifunctional cytokines
• TGFb controlling embryo development and tissue homeostasis
• TGFb receptor serine/threonine kinases
• SMADs as central TGFb signal transducers and transcriptional mediators
• Logic and organization of TGFb signaling processes
• TGFb pathway regulation and integration in the cell
• TGFb pathway disruption in heritable disorders and cancer

Links

Series:

• The Molecular Basis of Cancer
• Protein Phosphorylation

Categories:

• Biochemistry

Talk Citation

Publication History

• Published on November 30, 2010

Financial Disclosures

• Prof. Joan Massagué has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.