• General Aspects of Neuroscience Drug Discovery and Development
• 55 min
  1. Is there a role for academia in drug discovery

  • Dr. Adrian J. Ivinson
• 33 min
  2. Receptor-channel research at the interface between academia and pharma

  • Prof. Mihaly Hajos
• Seizure Disorders
• 35 min
  3. Discovery of Levetiracetam (Keppra(R)): The first SV2A ligand for the treatment of epilepsy

  • Dr. Henrik Klitgaard
• 47 min
  4. Anti-seizure drugs: discovery and development

  • Dr. Roger Porter
• Alzheimer's Disease
• 54 min
  5. Abeta toxicity 1

  • Prof. Colin L. Masters
• 28 min
  6. Abeta toxicity 2

  • Prof. Colin L. Masters
• 68 min
  7. Targeting Aß oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer’s disease

  • Prof. William L. Klein
• 19 min
  8. Pathogenic mechanisms and therapeutic approaches for the tauopathies

  • Prof. Karen Duff
• 31 min
  9. Update on fluid biomarkers for neurodegenerative diseases

  • Prof. Henrik Zetterberg
• Parkinson's Disease
• 51 min
  10. Disease-modifying therapies for Parkinson's disease

  • Dr. Todd Sherer
• Schizophrenia
• 20 min
  11. Discovery of schizophrenia drug targets from DISC1 mechanisms

  • Prof. Atsushi Kamiya
• 33 min
  12. Animal models for schizophrenia

  • Dr. Mikhail Pletnikov
• Archived Lectures *These may not cover the latest advances in the field
• 23 min
  13. Biomarkers for Alzheimer's disease

  • Prof. Henrik Zetterberg

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Alzheimer disease pathology
3. Tau-containing tangles and related lesions
4. Aberrant splicing of tau gene can cause tauopathy
5. Pathogenic mechanisms in tauopathy
6. Targets for drug development in the tauopathies
7. Reduction of tau by immunotherapy
8. Phospho-tau as a target
9. GSK3 inhibition via lithium
10. Tau-microtubule interaction as a target
11. Degradation of abnormal tau as a target
12. Disaggregation of tau as a target
13. Enhanced neuroprotection as a target
14. Summary

Topics Covered

• Tauopathies
• Alzheimer's Disease and frontal temporal lobe dementia
• Pathogenic mechanisms
• Therapeutic approaches for the tauopathies

Links

Series:

• Alzheimer's Disease
• Drug Discovery and Development in the Neurosciences

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on August 26, 2010

Financial Disclosures

• Prof. Karen Duff has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.