Registration for a live webinar on 'Innovative Vaccines and Viral Pathogenesis: Insights from Recent Monkeypox Research' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Introduction
-
1. DNA methylation during development
- Prof. Howard Cedar
- The Nuts and Bolts of DNA Methylation
-
2. DNA methylation patterns in mammals
- Prof. John Greally
-
3. Proteins that bind methylated DNA
- Dr. Pierre-Antoine Defossez
- DNA Methylation and Normal Physiology
-
4. Genomic imprinting
- Prof. Marisa Bartolomei
-
5. DNA methylation and stem cells
- Dr. Alexander Meissner
- DNA Methylation and the Pathophysiology of Disease
-
6. DNA methylation changes in aging cells and tissues
- Prof. Jean-Pierre Issa
-
7. DNA methylation in cancer
- Prof. Paula Vertino
-
8. Epigenomics of complex disease
- Prof. Art Petronis
-
9. DNA methylation, inflammation and cancer
- Prof. Gerd Pfeifer
- Clinical Applications of DNA Methylation Research
-
11. Reversing DNA methylation pharmacologically
- Dr. Allen Yang
Printable Handouts
Navigable Slide Index
- Introduction
- DNA methylation
- Methylation of CpG islands
- Analysis of CpG islands methylation
- CpG islands in the genome
- Example of un-methylated genes
- Example of methylated genes
- DNA methylation and gene relationship
- Methylation of transcription start sites
- Methylation motifs
- What determines methylation state?
- Describing the process
- Verification of the algorithm
- Methylation state at implantation
- The mechanism of turning off genes
- Tissue specific methylation
- De novo methylation events
- Methylation and gene activity
- The polycomb mark
- Abnormal de novo methylation in cancer
- Morphology of the colon
- Methylation of proliferative cells
- What is the trigger for de novo methylation?
- Methylation as a function of age
- Conclusion
Topics Covered
- Methylation of CpG islands in the genome
- Un-methylated/methylated genes
- DNA methylation and gene relationship
- Methylation of transcription start sites
- Methylation motifs
- What determines methylation state?
- Methylation predicting algorithm
- Methylation state at implantation
- The mechanism of turning off genes
- Tissue specific methylation
- De novo methylation events
- Methylation and gene activity
- The polycomb mark
- Abnormal methylation in cancer
- Methylation of proliferative cells
- Methylation as a function of age
Talk Citation
Cedar, H. (2020, July 12). DNA methylation during development [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 9, 2024, from https://doi.org/10.69645/ULKQ9469.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Howard Cedar has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.