• Evolutionary Perspectives
• 42 min
  1. Antibiotic resistance: a mechanistic overview

  • Dr. Neil Woodford
• 20 min
  2. Mutation

  • Prof. Stephen Gillespie
• 11 min
  3. Fitness in antibiotic resistant bacteria

  • Prof. Stephen Gillespie
• 34 min
  4. Fitness and compensation

  • Dr. Sébastian Gagneux
• 22 min
  5. Antibiotic resistance and the supragenome hypothesis

  • Dr. Bambos Charalambous
• Epidemiology and Clinical Impact
• 37 min
  6. Methicillin resistant S. aureus and other resistances

  • Prof. Mark Enright
• 43 min
  7. Risk factors for antibiotic resistance in Streptococcus pneumoniae

  • Prof. Keith Klugman
• 38 min
  8. Beta-lactamases: clinical impact and epidemiology

  • Prof. Sebastian Amyes
• 49 min
  9. Glycopeptide-resistant enterococci

  • Dr. Neil Woodford
• 33 min
  10. Drug resistant tuberculosis: biology, epidemiology and control

  • Dr. Christopher Dye
• 26 min
  11. Antiretroviral drug resistance

  • Prof. Deenan Pillay
• 49 min
  12. Malaria - changing paradigms

  • Dr. Janet Cox-Singh
• 42 min
  13. Advances in mode of action of antimalarials and resistance mechanisms 1

  • Prof. David Warhurst
• 38 min
  14. Advances in mode of action of antimalarials and resistance mechanisms 2

  • Prof. David Warhurst
• Diagnosis and Surveillance of Resistance
• 29 min
  15. Conventional and automated diagnostic methods

  • Dr. Alan Johnson
• 38 min
  16. National and international surveillance of antibiotic resistance 1

  • Prof. David Livermore
• 50 min
  17. National and international surveillance of antibiotic resistance 2

  • Prof. David Livermore
• Controlling Antibiotic Resistance
• 39 min
  18. Controlling antibiotic resistance in the hospital environment

  • Dr. Ian Eltringham
• 27 min
  19. Controlling antibiotic resistance in the community

  • Dr. Peter Wilson
• 51 min
  20. Public policy to reduce antibiotic resistance

  • Dr. Niels Frimodt-Møller
• The Antibiotic Resistance Future
• 26 min
  21. Overcoming resistance through novel drug targets

  • Prof. Anthony Coates
• 37 min
  22. Medicinal chemistry strategies in combating antibiotic resistance

  • Dr. Geoffrey Coxon
• 36 min
  23. Teixobactin kills pathogens without detectable resistance

  • Prof. Kim Lewis
• Archived Lectures *These may not cover the latest advances in the field
• 48 min
  24. Molecular diagnosis of antibiotic resistance

  • Dr. Tim McHugh
• 36 min
  25. Introduction to malaria

  • Prof. David Warhurst

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. Introduction of resistance
4. Drug discovery process
5. Antibiotic resistance - two fundamental questions
6. Mechanisms of antibiotic action
7. Mechanisms of antibiotic resistance: efflux pumps
8. Modification of the antibiotic pharmacophore
9. Modification of the target structure
10. Targeting existing therapy and resistance
11. b-lactamase inhibition combined with antibiotic
12. Avoiding efflux pump mechanisms
13. Overcoming modification in the target structure (1)
14. Overcoming modification in the target structure (2)
15. Considerations and methods
16. Factors for consideration: target (genomic) based
17. Factors for consideration: whole cell based
18. Target (genomic) based approaches
19. "HIT" or "lead" discovery approaches
20. Fragment based drug discovery
21. HTS vs. fragment based approach
22. Modelling: ligand and structure known approach
23. The development of benzoylaminobenzolic acids
24. Modelling: structure known but ligand unknown
25. Discovery of bacterial MurD and MurE inhibitors
26. Modelling: ligand known but structure unknown
27. Virtual screening efforts
28. Target (genomic) based approaches: summary
29. Whole cell (empirical) based approaches
30. Selection of chemical starting points (1)
31. Selection of chemical starting points (2)
32. Discovery of a new class of anti-TB agent (1)
33. Discovery of a new class of anti-TB agent (2)
34. Whole cell based approaches: summary
35. General summary

Topics Covered

• Overview of the drug discovery process
• Mechanisms of antibiotic action and resistance
• Modification of the antibiotic pharmacophore
• Modification of the target structure
• Targeting existing therapy and resistance mechanisms
• Overcoming modification in the target structure
• Considerations and methods in the discovery of new antibiotics
• Genomic based approaches
• Lead discovery approaches
• Fragment based drug discovery
• Modelling: ligand and structure known approach
• Modelling: structure known but ligand unknown approach
• Modelling: ligand known but structure unknown
• Whole cell (empirical) based approaches
• Selection of chemical starting points

Links

Series:

• Antibiotic Resistance

Categories:

• Microbiology
• Pharmaceutical Sciences

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on December 31, 2009

Financial Disclosures

• Dr. Geoffrey Coxon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.